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Clustering HLA Class I Superfamilies Using Structural Interaction Patterns
Human leukocyte antigen (HLA) class I molecules are critical components of the cell-mediated immune system that bind and present intracellular antigenic peptides to CD8(+) T cell receptors. To understand the interaction mechanism underlying human leukocyte antigen (HLA) class I specificity in detail...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903569/ https://www.ncbi.nlm.nih.gov/pubmed/24475163 http://dx.doi.org/10.1371/journal.pone.0086655 |
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author | Harjanto, Sumitro Ng, Lisa F. P. Tong, Joo Chuan |
author_facet | Harjanto, Sumitro Ng, Lisa F. P. Tong, Joo Chuan |
author_sort | Harjanto, Sumitro |
collection | PubMed |
description | Human leukocyte antigen (HLA) class I molecules are critical components of the cell-mediated immune system that bind and present intracellular antigenic peptides to CD8(+) T cell receptors. To understand the interaction mechanism underlying human leukocyte antigen (HLA) class I specificity in detail, we studied the structural interaction characteristics of 16,393 nonameric peptides binding to 58 HLA-A and -B molecules. Our analysis showed for the first time that HLA-peptide intermolecular bonding patterns vary among different alleles and may be grouped in a superfamily dependent manner. Through the use of these HLA class I ‘fingerprints’, a high resolution HLA class I superfamily classification schema was developed. This classification is capable of separating HLA alleles into well resolved, non-overlapping clusters, which is consistent with known HLA superfamily definitions. Such structural interaction approach serves as an excellent alternative to the traditional methods of HLA superfamily definitions that use peptide binding motifs or receptor information, and will help identify appropriate antigens suitable for broad-based subunit vaccine design. |
format | Online Article Text |
id | pubmed-3903569 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39035692014-01-28 Clustering HLA Class I Superfamilies Using Structural Interaction Patterns Harjanto, Sumitro Ng, Lisa F. P. Tong, Joo Chuan PLoS One Research Article Human leukocyte antigen (HLA) class I molecules are critical components of the cell-mediated immune system that bind and present intracellular antigenic peptides to CD8(+) T cell receptors. To understand the interaction mechanism underlying human leukocyte antigen (HLA) class I specificity in detail, we studied the structural interaction characteristics of 16,393 nonameric peptides binding to 58 HLA-A and -B molecules. Our analysis showed for the first time that HLA-peptide intermolecular bonding patterns vary among different alleles and may be grouped in a superfamily dependent manner. Through the use of these HLA class I ‘fingerprints’, a high resolution HLA class I superfamily classification schema was developed. This classification is capable of separating HLA alleles into well resolved, non-overlapping clusters, which is consistent with known HLA superfamily definitions. Such structural interaction approach serves as an excellent alternative to the traditional methods of HLA superfamily definitions that use peptide binding motifs or receptor information, and will help identify appropriate antigens suitable for broad-based subunit vaccine design. Public Library of Science 2014-01-27 /pmc/articles/PMC3903569/ /pubmed/24475163 http://dx.doi.org/10.1371/journal.pone.0086655 Text en © 2014 Harjanto et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Harjanto, Sumitro Ng, Lisa F. P. Tong, Joo Chuan Clustering HLA Class I Superfamilies Using Structural Interaction Patterns |
title | Clustering HLA Class I Superfamilies Using Structural Interaction Patterns |
title_full | Clustering HLA Class I Superfamilies Using Structural Interaction Patterns |
title_fullStr | Clustering HLA Class I Superfamilies Using Structural Interaction Patterns |
title_full_unstemmed | Clustering HLA Class I Superfamilies Using Structural Interaction Patterns |
title_short | Clustering HLA Class I Superfamilies Using Structural Interaction Patterns |
title_sort | clustering hla class i superfamilies using structural interaction patterns |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903569/ https://www.ncbi.nlm.nih.gov/pubmed/24475163 http://dx.doi.org/10.1371/journal.pone.0086655 |
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