Lethal Giant Larvae 1 Tumour Suppressor Activity Is Not Conserved in Models of Mammalian T and B Cell Leukaemia

In epithelial and stem cells, lethal giant larvae (Lgl) is a potent tumour suppressor, a regulator of Notch signalling, and a mediator of cell fate via asymmetric cell division. Recent evidence suggests that the function of Lgl is conserved in mammalian haematopoietic stem cells and implies a contri...

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Detalles Bibliográficos
Autores principales: Hawkins, Edwin D., Oliaro, Jane, Ramsbottom, Kelly M., Ting, Stephen B., Sacirbegovic, Faruk, Harvey, Michael, Kinwell, Tanja, Ghysdael, Jacques, Johnstone, Ricky W., Humbert, Patrick O., Russell, Sarah M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903681/
https://www.ncbi.nlm.nih.gov/pubmed/24475281
http://dx.doi.org/10.1371/journal.pone.0087376

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3903681/
https://www.ncbi.nlm.nih.gov/pubmed/24475281
http://dx.doi.org/10.1371/journal.pone.0087376

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