Cargando…

Patients with the most advanced rheumatoid arthritis remain with Th1 systemic defects after TNF inhibitors treatment despite clinical improvement

Systemic immune defects might reflect severely dysregulated control of chronic inflammation related to disease progression. Th17/Treg cell imbalance has been demonstrated to be involved in rheumatoid arthritis (RA) pathogenesis. Despite controversial results, a growing anti-inflammatory role in this...

Descripción completa

Detalles Bibliográficos
Autores principales:	Kosmaczewska, Agata, Swierkot, Jerzy, Ciszak, Lidia, Szteblich, Aleksandra, Chrobak, Agnieszka, Karabon, Lidia, Partyka, Anna, Szechinski, Jacek, Wiland, Piotr, Frydecka, Irena
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2013
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904036/ https://www.ncbi.nlm.nih.gov/pubmed/24221190 http://dx.doi.org/10.1007/s00296-013-2895-9

Ejemplares similares

Alterations in Both the Activatory and Inhibitory Potential of Peripheral Blood CD4+ T Cells in Rheumatoid Arthritis Patients Correlate with Disease Progression
por: Kosmaczewska, Agata, et al.
Publicado: (2013)

Exogenous IL-2 Controls the Balance in Th1, Th17, and Treg Cell Distribution in Patients with Progressive Rheumatoid Arthritis Treated with TNF-Alpha Inhibitors
por: Kosmaczewska, Agata, et al.
Publicado: (2014)

Patients with chronic lymphocytic leukaemia (CLL) differ in the pattern of CTLA-4 expression on CLL cells: the possible implications for immunotherapy with CTLA-4 blocking antibody
por: Ciszak, Lidia, et al.
Publicado: (2015)

CTLA-4 affects expression of key cell cycle regulators of G0/G1 phase in neoplastic lymphocytes from patients with chronic lymphocytic leukaemia
por: Ciszak, Lidia, et al.
Publicado: (2015)

Dysregulated Expression of Both the Costimulatory CD28 and Inhibitory CTLA-4 Molecules in PB T Cells of Advanced Cervical Cancer Patients Suggests Systemic Immunosuppression Related to Disease Progression
por: Kosmaczewska, Agata, et al.
Publicado: (2011)

BTLA Expression in CLL: Epigenetic Regulation and Impact on CLL B Cell Proliferation and Ability to IL-4 Production
por: Karabon, Lidia, et al.
Publicado: (2021)

Imbalance in PB IL-17-Secreting and Regulatory Cells in Pars Planitis Is Associated with Dysregulation of IFN-γ-Secreting Cells, Especially in Patients with Clinical Complications
por: Kosmaczewska, Agata, et al.
Publicado: (2020)

Deregulated Expression of Immune Checkpoints on Circulating CD4 T Cells May Complicate Clinical Outcome and Response to Treatment with Checkpoint Inhibitors in Multiple Myeloma Patients
por: Kulikowska de Nałęcz, Anna, et al.
Publicado: (2021)

Inappropriate Expression of PD-1 and CTLA-4 Checkpoints in Myeloma Patients Is More Pronounced at Diagnosis: Implications for Time to Progression and Response to Therapeutic Checkpoint Inhibitors
por: Kulikowska de Nałęcz, Anna, et al.
Publicado: (2023)

Abnormal Expression of BTLA and CTLA-4 Immune Checkpoint Molecules in Chronic Lymphocytic Leukemia Patients
por: Karabon, L., et al.
Publicado: (2020)

Gene Polymorphisms of Novel Immunotolerant Molecule BTLA: Distribution of Alleles, Genotypes and Haplotypes in Polish Caucasian Population
por: Partyka, Anna, et al.
Publicado: (2014)

Influence of NKG2D Genetic Variants on Response to Anti-TNF Agents in Patients with Rheumatoid Arthritis
por: Iwaszko, Milena, et al.
Publicado: (2018)

Variation in the gene encoding the co-inhibitory molecule BTLA is associated with survival in patients treated for clear cell renal carcinoma – results of a prospective cohort study
por: Tupikowski, Krzysztof, et al.
Publicado: (2021)

The effect of peripheral blood lymphocyte stimulation on zeta chain expression and IL-2 production in Hodgkin's disease
por: Frydecka, I, et al.
Publicado: (2001)

CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves’ disease and modulates clinical phenotype of disease
por: Pawlak-Adamska, Edyta, et al.
Publicado: (2016)

Erratum to: CD28/CTLA-4/ICOS haplotypes confers susceptibility to Graves’ disease and modulates clinical phenotype of disease
por: Pawlak-Adamska, Edyta, et al.
Publicado: (2017)

A CT60G>A polymorphism in the CTLA-4 gene of the recipient may confer susceptibility to acute graft versus host disease after allogeneic hematopoietic stem cell transplantation
por: Karabon, Lidia, et al.
Publicado: (2015)

Addendum: Iwaszko et al., Influence of NKG2D Genetic Variants on Response to Anti-TNF Agents in Patients with Rheumatoid Arthritis. Genes 2018, 9, 64
por: Iwaszko, Milena, et al.
Publicado: (2018)

Assessment of the Effect of Methotrexate Therapy on Bone Metabolism in Patients with Rheumatoid Arthritis
por: Świerkot, Jerzy, et al.
Publicado: (2015)

The Influence of Genetic Variations in the CD86 Gene on the Outcome after Allogeneic Hematopoietic Stem Cell Transplantation
por: Karabon, Lidia, et al.
Publicado: (2018)

Alterations of the expression of T-cell-related costimulatory CD28 and downregulatory CD152 (CTLA-4) molecules in patients with B-cell chronic lymphocytic leukaemia
por: Frydecka, I, et al.
Publicado: (2004)

Intragenic Variations in BTLA Gene Influence mRNA Expression of BTLA Gene in Chronic Lymphocytic Leukemia Patients and Confer Susceptibility to Chronic Lymphocytic Leukemia
por: Karabon, Lidia, et al.
Publicado: (2016)

Methotrexate treatment for rheumatoid arthritis in Poland: Retrospective analysis of patients in routine clinical practice
por: Świerkot, Jerzy, et al.
Publicado: (2018)

Association of MICA-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis
por: Iwaszko, Milena, et al.
Publicado: (2020)

sFasL-mediated induction of neutrophil activation in patients with type 2 diabetes mellitus
por: Margaryan, Sona, et al.
Publicado: (2018)

Genetic variants in transforming growth factor-β gene (TGFB1) affect susceptibility to schizophrenia
por: Frydecka, Dorota, et al.
Publicado: (2013)

Prevalence and clinical characteristics of rheumatoid arthritis in Poland: a nationwide study
por: Batko, Bogdan, et al.
Publicado: (2017)

Polymorphisms within Genes Involved in Regulation of the NF-κB Pathway in Patients with Rheumatoid Arthritis
por: Gębura, Katarzyna, et al.
Publicado: (2017)

Disease Differentiation and Monitoring of Anti-TNF Treatment in Rheumatoid Arthritis and Spondyloarthropathies
por: Bogunia-Kubik, Katarzyna, et al.
Publicado: (2021)

The role of diet in rheumatoid arthritis
por: Skoczyńska, Marta, et al.
Publicado: (2018)

The association of BTLA gene polymorphisms with non-small lung cancer risk in smokers and never-smokers
por: Andrzejczak, Anna, et al.
Publicado: (2023)

IL-17A, IL-17F and IL-23R Gene Polymorphisms in Polish Patients with Rheumatoid Arthritis
por: Bogunia-Kubik, Katarzyna, et al.
Publicado: (2014)

Variations in Suppressor Molecule CTLA-4 Gene Are Related to Susceptibility to Multiple Myeloma in a Polish Population
por: Karabon, Lidia, et al.
Publicado: (2011)

Exploring the Extracellular Vesicle MicroRNA Expression Repertoire in Patients with Rheumatoid Arthritis and Ankylosing Spondylitis Treated with TNF Inhibitors
por: Wielińska, Joanna, et al.
Publicado: (2021)

Changes in MiRNA-5196 Expression as a Potential Biomarker of Anti-TNF-α Therapy in Rheumatoid Arthritis and Ankylosing Spondylitis Patients
por: Ciechomska, Marzena, et al.
Publicado: (2018)

Polymorphisms of genes encoding cytokines predict the risk of high-grade bladder cancer and outcomes of BCG immunotherapy
por: KRAJEWSKI, WOJCIECH, et al.
Publicado: (2020)

Interleukin-6: the missing element of the neurocognitive deterioration in schizophrenia? The focus on genetic underpinnings, cognitive impairment and clinical manifestation
por: Frydecka, Dorota, et al.
Publicado: (2014)

Sex differences in TGFB-β signaling with respect to age of onset and cognitive functioning in schizophrenia
por: Frydecka, Dorota, et al.
Publicado: (2015)

IL-33 Gene Polymorphisms as Potential Biomarkers of Disease Susceptibility and Response to TNF Inhibitors in Rheumatoid Arthritis, Ankylosing Spondylitis, and Psoriatic Arthritis Patients
por: Iwaszko, Milena, et al.
Publicado: (2021)

Photo ID verification remains challenging despite years of practice
por: Papesh, Megan H.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_p585sv81hhg27cpveo5g82s8t5