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The unusual stoichiometry of ADP activation of the K(ATP) channel

K(ATP) channels, oligomers of 4 pore-forming Kir6.2 proteins and 4 sulfonylurea receptors (SUR), sense metabolism by monitoring both cytosolic ATP, which closes the channel by interacting with Kir6.2, and ADP, which opens it via SUR. SUR mutations that alter activation by ADP are a major cause of K(...

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Detalles Bibliográficos
Autores principales:	Hosy, Eric, Vivaudou, Michel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2014
Materias:	Physiology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904077/ https://www.ncbi.nlm.nih.gov/pubmed/24478723 http://dx.doi.org/10.3389/fphys.2014.00011

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