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Distinct patterns of spread of prion infection in brains of mice expressing anchorless or anchored forms of prion protein
BACKGROUND: In humans and animals, prion protein (PrP) is usually expressed as a glycophosphatidylinositol (GPI)-anchored membrane protein, but anchorless PrP may be pathogenic in humans with certain familial prion diseases. Anchored PrP expressed on neurons mediates spread of prions along axons in...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904166/ https://www.ncbi.nlm.nih.gov/pubmed/24447368 http://dx.doi.org/10.1186/2051-5960-2-8 |