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Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population
Plasma lipid abnormalities are implicated in the pathogenic process of type 2 diabetes. The IDE-KIF11-HHEX gene cluster on chromosome 10q23.33 has been identified as a susceptibility locus for type 2 diabetes. We hypothesized that genetic variants at 10q23.33 may be associated with plasma lipid conc...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Editorial Department of Journal of Biomedical Research
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904175/ https://www.ncbi.nlm.nih.gov/pubmed/24474964 http://dx.doi.org/10.7555/JBR.27.20120091 |
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author | Liu, Sijun Qian, Yun Lu, Feng Dong, Meihua Lin, Yudi Li, Huizhang Shen, Chong Dai, Juncheng Jiang, Yue Jin, Guangfu Hu, Zhibin Shen, Hongbing |
author_facet | Liu, Sijun Qian, Yun Lu, Feng Dong, Meihua Lin, Yudi Li, Huizhang Shen, Chong Dai, Juncheng Jiang, Yue Jin, Guangfu Hu, Zhibin Shen, Hongbing |
author_sort | Liu, Sijun |
collection | PubMed |
description | Plasma lipid abnormalities are implicated in the pathogenic process of type 2 diabetes. The IDE-KIF11-HHEX gene cluster on chromosome 10q23.33 has been identified as a susceptibility locus for type 2 diabetes. We hypothesized that genetic variants at 10q23.33 may be associated with plasma lipid concentrations. Seven tagging single nucleotide polymorphisms (SNPs: rs7923837, rs2488075, rs947591, rs11187146, rs5015480, rs4646957 and rs1111875) at 10q23.33 were genotyped in 3,281 subjects from a Han Chinese population, using the TaqMan OpenArray and Sequenom MassARRAY platforms. Multiple linear regression analyses showed that SNP rs7923837 in the 3′-flanking region of HHEX was significantly associated with triglyceride levels (P = 0.019, 0.031 mmol/L average decrease per minor G allele) and that rs2488075 and rs947591 in the downstream region of HHEX were significantly associated with total cholesterol levels (P = 0.041, 0.058 mmol/L average decrease per minor C allele and P = 0.018, 0.063 mmol/L average decrease per minor A allele, respectively). However, the other four SNPs (rs11187146, rs5015480, rs4646957 and rs1111875) were not significantly associated with any plasma lipid concentrations in this Chinese population. Our data suggest that genetic variants in the IDE-KIF11-HHEX gene cluster at 10q23.33 may partially explain the variation of plasma lipid levels in the Han Chinese population. Further studies are required to confirm these findings in other populations. |
format | Online Article Text |
id | pubmed-3904175 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Editorial Department of Journal of Biomedical Research |
record_format | MEDLINE/PubMed |
spelling | pubmed-39041752014-01-28 Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population Liu, Sijun Qian, Yun Lu, Feng Dong, Meihua Lin, Yudi Li, Huizhang Shen, Chong Dai, Juncheng Jiang, Yue Jin, Guangfu Hu, Zhibin Shen, Hongbing J Biomed Res Research Paper Plasma lipid abnormalities are implicated in the pathogenic process of type 2 diabetes. The IDE-KIF11-HHEX gene cluster on chromosome 10q23.33 has been identified as a susceptibility locus for type 2 diabetes. We hypothesized that genetic variants at 10q23.33 may be associated with plasma lipid concentrations. Seven tagging single nucleotide polymorphisms (SNPs: rs7923837, rs2488075, rs947591, rs11187146, rs5015480, rs4646957 and rs1111875) at 10q23.33 were genotyped in 3,281 subjects from a Han Chinese population, using the TaqMan OpenArray and Sequenom MassARRAY platforms. Multiple linear regression analyses showed that SNP rs7923837 in the 3′-flanking region of HHEX was significantly associated with triglyceride levels (P = 0.019, 0.031 mmol/L average decrease per minor G allele) and that rs2488075 and rs947591 in the downstream region of HHEX were significantly associated with total cholesterol levels (P = 0.041, 0.058 mmol/L average decrease per minor C allele and P = 0.018, 0.063 mmol/L average decrease per minor A allele, respectively). However, the other four SNPs (rs11187146, rs5015480, rs4646957 and rs1111875) were not significantly associated with any plasma lipid concentrations in this Chinese population. Our data suggest that genetic variants in the IDE-KIF11-HHEX gene cluster at 10q23.33 may partially explain the variation of plasma lipid levels in the Han Chinese population. Further studies are required to confirm these findings in other populations. Editorial Department of Journal of Biomedical Research 2014-01 2012-12-20 /pmc/articles/PMC3904175/ /pubmed/24474964 http://dx.doi.org/10.7555/JBR.27.20120091 Text en © 2014 by the Journal of Biomedical Research. All rights reserved. |
spellingShingle | Research Paper Liu, Sijun Qian, Yun Lu, Feng Dong, Meihua Lin, Yudi Li, Huizhang Shen, Chong Dai, Juncheng Jiang, Yue Jin, Guangfu Hu, Zhibin Shen, Hongbing Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population |
title | Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population |
title_full | Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population |
title_fullStr | Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population |
title_full_unstemmed | Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population |
title_short | Genetic variants at 10q23.33 are associated with plasma lipid levels in a Chinese population |
title_sort | genetic variants at 10q23.33 are associated with plasma lipid levels in a chinese population |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904175/ https://www.ncbi.nlm.nih.gov/pubmed/24474964 http://dx.doi.org/10.7555/JBR.27.20120091 |
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