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Role of the vector genome and underlying factor IX mutation in immune responses to AAV gene therapy for hemophilia B
BACKGROUND: Self-complementary adeno-associated virus (scAAV) vectors have become a desirable vector for therapeutic gene transfer due to their ability to produce greater levels of transgene than single-stranded AAV (ssAAV). However, recent reports have suggested that scAAV vectors are more immunoge...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904690/ https://www.ncbi.nlm.nih.gov/pubmed/24460861 http://dx.doi.org/10.1186/1479-5876-12-25 |