Cargando…

Paxillin is an intrinsic negative regulator of platelet activation in mice

BACKGROUND: Paxillin is a LIM domain protein localized at integrin-mediated focal adhesions. Although paxillin is thought to modulate the functions of integrins, little is known about the contribution of paxillin to signaling pathways in platelets. Here, we studied the role of paxillin in platelet a...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sakata, Asuka, Ohmori, Tsukasa, Nishimura, Satoshi, Suzuki, Hidenori, Madoiwa, Seiji, Mimuro, Jun, Kario, Kazuomi, Sakata, Yoichi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Original Basic Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904695/ https://www.ncbi.nlm.nih.gov/pubmed/24383745 http://dx.doi.org/10.1186/1477-9560-12-1

Ejemplares similares

Combination of thrombin-antithrombin complex, plasminogen activator inhibitor-1, and protein C activity for early identification of severe coagulopathy in initial phase of sepsis: a prospective observational study
por: Koyama, Kansuke, et al.
Publicado: (2014)

Porcine Model of Hemophilia A
por: Kashiwakura, Yuji, et al.
Publicado: (2012)

Fibrinolytic components in nasal mucosa and nasal secretion
por: Yasuda, Toyotoshi, et al.
Publicado: (1998)

CRISPR/Cas9-mediated genome editing via postnatal administration of AAV vector cures haemophilia B mice
por: Ohmori, Tsukasa, et al.
Publicado: (2017)

Differential impact of diabetes mellitus on antiplatelet effects of prasugrel and clopidogrel
por: Niijima, Satoshi, et al.
Publicado: (2018)

Hemostatic function to regulate perioperative bleeding in patients undergoing spinal surgery: A prospective observational study
por: Kimura, Atsushi, et al.
Publicado: (2017)

Characterization and visualization of murine coagulation factor VIII-producing cells in vivo
por: Hayakawa, Morisada, et al.
Publicado: (2021)

Short-term inhibition of fibrinolytic system restores locomotor function after spinal cord injury in mice
por: Shiraishi, Yasuyuki, et al.
Publicado: (2019)

Utility of microminipigs for evaluating liver-mediated gene expression in the presence of neutralizing antibody against vector capsid
por: Watano, Ryota, et al.
Publicado: (2020)

IL-1α induces thrombopoiesis through megakaryocyte rupture in response to acute platelet needs
por: Nishimura, Satoshi, et al.
Publicado: (2015)

Freeze-Dried Platelet-Rich Plasma Induces Osteoblast Proliferation via Platelet-Derived Growth Factor Receptor-Mediated Signal Transduction
por: Kinoshita, Hideyuki, et al.
Publicado: (2020)

Infective Endocarditis Revealed after Resolution of COVID-19 Infection
por: Sakata, Tomohisa, et al.
Publicado: (2022)

M1 macrophage infiltration exacerbate muscle/bone atrophy after peripheral nerve injury
por: Shimada, Nobuhiro, et al.
Publicado: (2020)

The effect of mountaineering on the association between blood pressure and physical activity: A new multi‐sensor ambulatory blood‐pressure monitoring device. The Mount Fuji Study
por: Komori, Takahiro, et al.
Publicado: (2022)

Paxillin brings peace to microtubules
por: Leslie, Mitch
Publicado: (2014)

Recent advances in disseminated intravascular coagulation: endothelial cells and fibrinolysis in sepsis-induced DIC
por: Madoiwa, Seiji
Publicado: (2015)

Anti–nerve growth factor therapy attenuates cutaneous hypersensitivity and musculoskeletal discomfort in mice with osteoporosis
por: Suzuki, Miyako, et al.
Publicado: (2018)

Development of positive/negative pressure booth generating airflow for protection of medical staff from contagious respiratory pathogens
por: Nishimura, Hidekazu, et al.
Publicado: (2020)

Rationale, study design, and implementation of the ACS1 study: effect of azilsartan on circadian and sleep blood pressure as compared with amlodipine
por: Kario, Kazuomi, et al.
Publicado: (2014)

Development and Evaluation of Monoclonal Antibodies for Paxilline
por: Maragos, Chris M.
Publicado: (2015)

The LD4 motif of paxillin regulates cell spreading and motility through an interaction with paxillin kinase linker (PKL)
por: West, Kip A., et al.
Publicado: (2001)

Isolated Cardiac Sarcoidosis Mimicking Arrhythmogenic Right Ventricular Cardiomyopathy
por: Waki, Hirotaka, et al.
Publicado: (2017)

Single‐pill combination of cilnidipine, an l‐/n‐type calcium channel blocker, and valsartan reduces the day‐by‐day variability of morning home systolic blood pressure in patients with treated hypertension: A sub‐analysis of the HOPE‐combi survey
por: Kario, Kazuomi, et al.
Publicado: (2021)

Sleep Duration as a Risk Factor for Cardiovascular Disease- a Review of the Recent Literature
por: Nagai, Michiaki, et al.
Publicado: (2010)

Self‐measured worksite blood pressure and its association with organ damage in working adults: Japan Morning Surge Home Blood Pressure (J‐HOP) worksite study
por: Tomitani, Naoko, et al.
Publicado: (2020)

Association of lower nighttime diastolic blood pressure and hypoxia with silent myocardial injury: The Japan Morning Surge‐Home Blood Pressure study
por: Kubota, Kana, et al.
Publicado: (2020)

Digital Hypertension 2023: Concept, hypothesis, and new technology
por: Kario, Kazuomi, et al.
Publicado: (2022)

Cardiovascular Disease Prevention in Patients With Atherosclerotic Renovascular Disease‐Induced Resistant Hypertension: Further Considerations for 24‐Hour Blood Pressure Profiles
por: Narita, Keisuke, et al.
Publicado: (2022)

Changes in Blood Pressure Reactivity Against Physical Activity Evaluated by Multisensor-ABPM in Heart Failure Patients
por: Narita, Keisuke, et al.
Publicado: (2022)

Evolution and Expression of Paxillin Genes in Teleost Fish
por: Jacob, Andrew E., et al.
Publicado: (2016)

Paxillin: a crossroad in pathological cell migration
por: López-Colomé, Ana María, et al.
Publicado: (2017)

BK channel blocker paxilline attenuates thalidomide-caused synaptic and cognitive dysfunctions in mice
por: Choi, Tae-Yong, et al.
Publicado: (2018)

Differences in exercise‐induced blood pressure changes between young trained and untrained individuals
por: Nakamura, Kenji, et al.
Publicado: (2021)

Intrinsic Constraints on Sympodial Growth Morphologies of Azooxanthellate Scleractinian Coral Dendrophyllia
por: Sentoku, Asuka, et al.
Publicado: (2013)

Molecularly imprinted polymer-based bioelectrical interfaces with intrinsic molecular charges
por: Sakata, Toshiya, et al.
Publicado: (2020)

Post-marketing surveillance data of thrombomodulin alfa: sub-analysis in patients with sepsis-induced disseminated intravascular coagulation
por: Eguchi, Yutaka, et al.
Publicado: (2014)

Systemic Hemodynamic Atherothrombotic Syndrome and Resonance Hypothesis of Blood Pressure Variability: Triggering Cardiovascular Events
por: Kario, Kazuomi
Publicado: (2016)

Management of Hypertension in the Digital Era: Small Wearable Monitoring Devices for Remote Blood Pressure Monitoring
por: Kario, Kazuomi
Publicado: (2020)

Key Points of the 2019 Japanese Society of Hypertension Guidelines for the Management of Hypertension
por: Kario, Kazuomi
Publicado: (2019)

HOPE Asia Network Activity 2021—Collaboration and perspectives of Asia academic activity
por: Kario, Kazuomi
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_tkbl0e6ge6ufvkk8ajt34et4g9