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Increasing the Coverage of Medicinal Chemistry-Relevant Space in Commercial Fragments Screening

[Image: see text] Analyzing the chemical space coverage in commercial fragment screening collections revealed the overlap between bioactive medicinal chemistry substructures and rule-of-three compliant fragments is only ∼25%. We recommend including these fragments in fragment screening libraries to...

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Detalles Bibliográficos
Autores principales:	Mok, N. Yi, Brenk, Ruth, Brown, Nathan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904764/ https://www.ncbi.nlm.nih.gov/pubmed/24405118 http://dx.doi.org/10.1021/ci400632y

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