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Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis

This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to investigate real-time drug release in the deep skin in rats. We used a uniform design method to evaluate the effects of different ethosome formulations on entrapment efficiency and drug skin deposition....

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Autores principales: Zhang, Yong-Tai, Shen, Li-Na, Zhao, Ji-Hui, Feng, Nian-Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904810/
https://www.ncbi.nlm.nih.gov/pubmed/24489470
http://dx.doi.org/10.2147/IJN.S57314
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author Zhang, Yong-Tai
Shen, Li-Na
Zhao, Ji-Hui
Feng, Nian-Ping
author_facet Zhang, Yong-Tai
Shen, Li-Na
Zhao, Ji-Hui
Feng, Nian-Ping
author_sort Zhang, Yong-Tai
collection PubMed
description This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to investigate real-time drug release in the deep skin in rats. We used a uniform design method to evaluate the effects of different ethosome formulations on entrapment efficiency and drug skin deposition. Using in vitro and in vivo methods, we investigated skin penetration and release from psoralen-loaded ethosomes in comparison with an ethanol tincture. In in vitro studies, the use of ethosomes was associated with a 6.56-fold greater skin deposition of psoralen than that achieved with the use of the tincture. In vivo skin microdialysis showed that the peak concentration and area under the curve of psoralen from ethosomes were approximately 3.37 and 2.34 times higher, respectively, than those of psoralen from the tincture. Moreover, it revealed that the percutaneous permeability of ethosomes was greater when applied to the abdomen than when applied to the chest or scapulas. Enhanced permeation and skin deposition of psoralen delivered by ethosomes may help reduce toxicity and improve the efficacy of long-term psoralen treatment.
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spelling pubmed-39048102014-01-31 Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis Zhang, Yong-Tai Shen, Li-Na Zhao, Ji-Hui Feng, Nian-Ping Int J Nanomedicine Original Research This study aimed to improve skin permeation and deposition of psoralen by using ethosomes and to investigate real-time drug release in the deep skin in rats. We used a uniform design method to evaluate the effects of different ethosome formulations on entrapment efficiency and drug skin deposition. Using in vitro and in vivo methods, we investigated skin penetration and release from psoralen-loaded ethosomes in comparison with an ethanol tincture. In in vitro studies, the use of ethosomes was associated with a 6.56-fold greater skin deposition of psoralen than that achieved with the use of the tincture. In vivo skin microdialysis showed that the peak concentration and area under the curve of psoralen from ethosomes were approximately 3.37 and 2.34 times higher, respectively, than those of psoralen from the tincture. Moreover, it revealed that the percutaneous permeability of ethosomes was greater when applied to the abdomen than when applied to the chest or scapulas. Enhanced permeation and skin deposition of psoralen delivered by ethosomes may help reduce toxicity and improve the efficacy of long-term psoralen treatment. Dove Medical Press 2014-01-23 /pmc/articles/PMC3904810/ /pubmed/24489470 http://dx.doi.org/10.2147/IJN.S57314 Text en © 2014 Zhang et al. This work is published by Dove Medical Press Limited, and licensed under Creative Commons Attribution – Non Commercial (unported, v3.0) License The full terms of the License are available at http://creativecommons.org/licenses/by-nc/3.0/. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhang, Yong-Tai
Shen, Li-Na
Zhao, Ji-Hui
Feng, Nian-Ping
Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_full Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_fullStr Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_full_unstemmed Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_short Evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
title_sort evaluation of psoralen ethosomes for topical delivery in rats by using in vivo microdialysis
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904810/
https://www.ncbi.nlm.nih.gov/pubmed/24489470
http://dx.doi.org/10.2147/IJN.S57314
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