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Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study
An MRI biomarker for Parkinsonism has long been sought, but almost all attempts at conventional field strengths have proved unsatisfactory, since patients and controls are not separated. The exception is Spin-Lattice Distribution MRI (SLD-MRI), a technique which detects changes in the substantia nig...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904838/ https://www.ncbi.nlm.nih.gov/pubmed/24489655 http://dx.doi.org/10.1371/journal.pone.0085194 |
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author | Hutchinson, Michael Raff, Ulrich Chaná, Pedro Huete, Isidro |
author_facet | Hutchinson, Michael Raff, Ulrich Chaná, Pedro Huete, Isidro |
author_sort | Hutchinson, Michael |
collection | PubMed |
description | An MRI biomarker for Parkinsonism has long been sought, but almost all attempts at conventional field strengths have proved unsatisfactory, since patients and controls are not separated. The exception is Spin-Lattice Distribution MRI (SLD-MRI), a technique which detects changes in the substantia nigra (SN) due to changes in the spin-lattice relaxation time, T(1). This easily separates patients with Parkinson's disease (PD) from control subjects at 1.5 Tesla, suggesting that it may be sensitive to presymptomatic disease. SLD-MRI demonstrates a topography of signal change within the SN which is the same as the known topography of pathological change, where the lateral portions of the nucleus are more affected than the medial. In a further step towards its validation, we apply SLD-MRI to a disease control, Progressive Supranuclear Palsy (PSP), the most common of the atypical forms of Parkinsonism. In PSP the topography of pathological change in the SN is reversed. We therefore hypothesized that PSP would show a topography of SLD-MRI signal change in the SN that is the reverse of PD (i.e. the medial portion is more affected than the lateral). All 7 patients showed such a topography of MR signal, and all patients were separated from control subjects. Although this is a step toward validation of SLD-MRI with respect to sensitivity and disease specificity, nevertheless we stress that this is a pilot project only. Validation will only be possible when comparing larger cohorts of PSP, PD and control subjects. |
format | Online Article Text |
id | pubmed-3904838 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-39048382014-01-31 Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study Hutchinson, Michael Raff, Ulrich Chaná, Pedro Huete, Isidro PLoS One Research Article An MRI biomarker for Parkinsonism has long been sought, but almost all attempts at conventional field strengths have proved unsatisfactory, since patients and controls are not separated. The exception is Spin-Lattice Distribution MRI (SLD-MRI), a technique which detects changes in the substantia nigra (SN) due to changes in the spin-lattice relaxation time, T(1). This easily separates patients with Parkinson's disease (PD) from control subjects at 1.5 Tesla, suggesting that it may be sensitive to presymptomatic disease. SLD-MRI demonstrates a topography of signal change within the SN which is the same as the known topography of pathological change, where the lateral portions of the nucleus are more affected than the medial. In a further step towards its validation, we apply SLD-MRI to a disease control, Progressive Supranuclear Palsy (PSP), the most common of the atypical forms of Parkinsonism. In PSP the topography of pathological change in the SN is reversed. We therefore hypothesized that PSP would show a topography of SLD-MRI signal change in the SN that is the reverse of PD (i.e. the medial portion is more affected than the lateral). All 7 patients showed such a topography of MR signal, and all patients were separated from control subjects. Although this is a step toward validation of SLD-MRI with respect to sensitivity and disease specificity, nevertheless we stress that this is a pilot project only. Validation will only be possible when comparing larger cohorts of PSP, PD and control subjects. Public Library of Science 2014-01-28 /pmc/articles/PMC3904838/ /pubmed/24489655 http://dx.doi.org/10.1371/journal.pone.0085194 Text en © 2014 Hutchinson et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited. |
spellingShingle | Research Article Hutchinson, Michael Raff, Ulrich Chaná, Pedro Huete, Isidro Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study |
title | Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study |
title_full | Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study |
title_fullStr | Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study |
title_full_unstemmed | Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study |
title_short | Spin-Lattice Distribution MRI Maps Nigral Pathology in Progressive Supranuclear Palsy (PSP) during Life: A Pilot Study |
title_sort | spin-lattice distribution mri maps nigral pathology in progressive supranuclear palsy (psp) during life: a pilot study |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904838/ https://www.ncbi.nlm.nih.gov/pubmed/24489655 http://dx.doi.org/10.1371/journal.pone.0085194 |
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