Sodium Current Reduction Unmasks a Structure-Dependent Substrate for Arrhythmogenesis in the Normal Ventricles

BACKGROUND: Organ-scale arrhythmogenic consequences of source-sink mismatch caused by impaired excitability remain unknown, hindering the understanding of pathophysiology in disease states like Brugada syndrome and ischemia. OBJECTIVE: We sought to determine whether sodium current (I(Na)) reduction...

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Detalles Bibliográficos
Autores principales: Boyle, Patrick M., Park, Carolyn J., Arevalo, Hermenegild J., Vigmond, Edward J., Trayanova, Natalia A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904970/
https://www.ncbi.nlm.nih.gov/pubmed/24489810
http://dx.doi.org/10.1371/journal.pone.0086947

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