A Ser252Trp Mutation in Fibroblast Growth Factor Receptor 2 (FGFR2) Mimicking Human Apert Syndrome Reveals an Essential Role for FGF Signaling in the Regulation of Endochondral Bone Formation

A S252W mutation of fibroblast growth factor receptor 2 (FGFR2), which is responsible for nearly two-thirds of Apert syndrome (AS) cases, causes retarded development of the skeleton and skull malformation resulting from premature fusion of the craniofacial sutures. We utilized a Fgfr2(+/S252W) mouse...

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Detalles Bibliográficos
Autores principales: Chen, Peng, Zhang, Li, Weng, Tujun, Zhang, Shichang, Sun, Shijin, Chang, Mingtao, Li, Yang, Zhang, Bo, Zhang, Lianyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3904987/
https://www.ncbi.nlm.nih.gov/pubmed/24489893
http://dx.doi.org/10.1371/journal.pone.0087311

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