Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives

A series of arylpiperazine derivatives of 1,16-diphenyl-19-azahexacyclo-[14.5.1.0(2,15).0(3,8).0(9,14).0(17,21)]docosa-2,3,5,7,8,9,11,13,14-nonaene-18,20,22-trione and 4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione was synthesized. The pharmacological profile of compound 4 at the 5-HT...

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Autores principales: Szulczyk, Daniel, Bielenica, Anna, Dobrowolski, Michał A., Dobrzycki, Łukasz, Krawiecka, Mariola, Kuran, Bożena, Struga, Marta
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2013
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905170/
https://www.ncbi.nlm.nih.gov/pubmed/24489455
http://dx.doi.org/10.1007/s00044-013-0740-z
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author Szulczyk, Daniel
Bielenica, Anna
Dobrowolski, Michał A.
Dobrzycki, Łukasz
Krawiecka, Mariola
Kuran, Bożena
Struga, Marta
author_facet Szulczyk, Daniel
Bielenica, Anna
Dobrowolski, Michał A.
Dobrzycki, Łukasz
Krawiecka, Mariola
Kuran, Bożena
Struga, Marta
author_sort Szulczyk, Daniel
collection PubMed
description A series of arylpiperazine derivatives of 1,16-diphenyl-19-azahexacyclo-[14.5.1.0(2,15).0(3,8).0(9,14).0(17,21)]docosa-2,3,5,7,8,9,11,13,14-nonaene-18,20,22-trione and 4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione was synthesized. The pharmacological profile of compound 4 at the 5-HT(1A) receptor was measured by binding assay. The title compounds were tested in cell-based assay against the human immunodeficiency virus type-1. The X-ray crystallographic studies of derivatives 2, 6, 7, 11, 19, and 20 were presented.
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spelling pubmed-39051702014-01-30 Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives Szulczyk, Daniel Bielenica, Anna Dobrowolski, Michał A. Dobrzycki, Łukasz Krawiecka, Mariola Kuran, Bożena Struga, Marta Med Chem Res Original Research A series of arylpiperazine derivatives of 1,16-diphenyl-19-azahexacyclo-[14.5.1.0(2,15).0(3,8).0(9,14).0(17,21)]docosa-2,3,5,7,8,9,11,13,14-nonaene-18,20,22-trione and 4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione was synthesized. The pharmacological profile of compound 4 at the 5-HT(1A) receptor was measured by binding assay. The title compounds were tested in cell-based assay against the human immunodeficiency virus type-1. The X-ray crystallographic studies of derivatives 2, 6, 7, 11, 19, and 20 were presented. Springer US 2013-09-03 2014 /pmc/articles/PMC3905170/ /pubmed/24489455 http://dx.doi.org/10.1007/s00044-013-0740-z Text en © The Author(s) 2013 https://creativecommons.org/licenses/by/2.0/ Open AccessThis article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Research
Szulczyk, Daniel
Bielenica, Anna
Dobrowolski, Michał A.
Dobrzycki, Łukasz
Krawiecka, Mariola
Kuran, Bożena
Struga, Marta
Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
title Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
title_full Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
title_fullStr Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
title_full_unstemmed Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
title_short Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
title_sort synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905170/
https://www.ncbi.nlm.nih.gov/pubmed/24489455
http://dx.doi.org/10.1007/s00044-013-0740-z
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