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Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels
Mineralocorticoid and glucocorticoid receptors (MRs and GRs) mediate the impact of stress on brain function primarily by affecting gene transcription in the cell nucleus. In vitro studies using hippocampal neurons indicate that MRs and GRs translocate to the nucleus after binding to the stress hormo...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905199/ https://www.ncbi.nlm.nih.gov/pubmed/24523684 http://dx.doi.org/10.3389/fnbeh.2014.00019 |
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author | Caudal, Dorian Jay, Thérèse M. Godsil, Bill P. |
author_facet | Caudal, Dorian Jay, Thérèse M. Godsil, Bill P. |
author_sort | Caudal, Dorian |
collection | PubMed |
description | Mineralocorticoid and glucocorticoid receptors (MRs and GRs) mediate the impact of stress on brain function primarily by affecting gene transcription in the cell nucleus. In vitro studies using hippocampal neurons indicate that MRs and GRs translocate to the nucleus after binding to the stress hormone corticosterone, yet the in vivo temporal dynamics of MR and GR levels in other limbic regions critical for the stress response, however, are largely unknown. Rats underwent an elevated platform (EP) stress procedure and brain tissue was sampled from the amygdala (AMY), medial prefrontal cortex (mPFC), dorsal hippocampus and ventral hippocampus. By measuring MR and GR levels in the nuclear fraction from the tissue sampled, we observed striking shifts in the protein levels that varied by receptor, brain region and by the time after EP stress. These findings indicate that the subcellular trafficking of corticosteroid receptors display distinct temporal dynamics in different limbic regions after behavioral stress. These heterogeneous effects could underlie contrasting regional responses to stress within the brain, and they highlight the importance for systems-level analysis of stress responsivity. |
format | Online Article Text |
id | pubmed-3905199 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39051992014-02-12 Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels Caudal, Dorian Jay, Thérèse M. Godsil, Bill P. Front Behav Neurosci Neuroscience Mineralocorticoid and glucocorticoid receptors (MRs and GRs) mediate the impact of stress on brain function primarily by affecting gene transcription in the cell nucleus. In vitro studies using hippocampal neurons indicate that MRs and GRs translocate to the nucleus after binding to the stress hormone corticosterone, yet the in vivo temporal dynamics of MR and GR levels in other limbic regions critical for the stress response, however, are largely unknown. Rats underwent an elevated platform (EP) stress procedure and brain tissue was sampled from the amygdala (AMY), medial prefrontal cortex (mPFC), dorsal hippocampus and ventral hippocampus. By measuring MR and GR levels in the nuclear fraction from the tissue sampled, we observed striking shifts in the protein levels that varied by receptor, brain region and by the time after EP stress. These findings indicate that the subcellular trafficking of corticosteroid receptors display distinct temporal dynamics in different limbic regions after behavioral stress. These heterogeneous effects could underlie contrasting regional responses to stress within the brain, and they highlight the importance for systems-level analysis of stress responsivity. Frontiers Media S.A. 2014-01-29 /pmc/articles/PMC3905199/ /pubmed/24523684 http://dx.doi.org/10.3389/fnbeh.2014.00019 Text en Copyright © 2014 Caudal, Jay and Godsil. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Caudal, Dorian Jay, Thérèse M. Godsil, Bill P. Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels |
title | Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels |
title_full | Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels |
title_fullStr | Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels |
title_full_unstemmed | Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels |
title_short | Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels |
title_sort | behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905199/ https://www.ncbi.nlm.nih.gov/pubmed/24523684 http://dx.doi.org/10.3389/fnbeh.2014.00019 |
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