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Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma

Recollection of emotional memories is attributed in part to the activation of the amygdala and the hippocampus. Recent hypothesis suggests a pivotal role for the ventral hippocampus (VH) in traumatic stress processing and emotional memory retrieval. Persistent re-experiencing and intrusive recollect...

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Autores principales: Ritov, Gilad, Ardi, Ziv, Richter-Levin, Gal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905214/
https://www.ncbi.nlm.nih.gov/pubmed/24523683
http://dx.doi.org/10.3389/fnbeh.2014.00018
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author Ritov, Gilad
Ardi, Ziv
Richter-Levin, Gal
author_facet Ritov, Gilad
Ardi, Ziv
Richter-Levin, Gal
author_sort Ritov, Gilad
collection PubMed
description Recollection of emotional memories is attributed in part to the activation of the amygdala and the hippocampus. Recent hypothesis suggests a pivotal role for the ventral hippocampus (VH) in traumatic stress processing and emotional memory retrieval. Persistent re-experiencing and intrusive recollections are core symptoms in acute and posttraumatic stress disorders (ASD; PTSD). Such intrusive recollections are often triggered by reminders associated with the trauma. We examined the impact of exposure to a trauma reminder (under water trauma (UWT)) on the activation of the basolateral amygdala (BLA), dorsal and VH. Rats were exposed to UWT and 24 h later were re-exposed to the context of the trauma. Phosphorylation of the extracellular signal-regulated kinase (ERK) was used as a marker for level of activation of these regions. Significant increase in ERK activation was found in the VH and BLA. Such pattern of activation was not found in animals exposed only to the trauma or in animals exposed only to the trauma reminder. Additionally, the dissociative pattern of activation of the VH sub-regions positively correlated with the activation of the BLA. Our findings suggest a specific pattern of neural activation during recollection of a trauma reminder, with a unique contribution of the VH. Measured 24 h after the exposure to the traumatic experience, the current findings relate to relatively early stages of traumatic memory consolidation. Understanding the neural mechanisms underlying these initial stages may contribute to developing intervention strategies that could reduce the risk of eventually developing PTSD.
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spelling pubmed-39052142014-02-12 Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma Ritov, Gilad Ardi, Ziv Richter-Levin, Gal Front Behav Neurosci Neuroscience Recollection of emotional memories is attributed in part to the activation of the amygdala and the hippocampus. Recent hypothesis suggests a pivotal role for the ventral hippocampus (VH) in traumatic stress processing and emotional memory retrieval. Persistent re-experiencing and intrusive recollections are core symptoms in acute and posttraumatic stress disorders (ASD; PTSD). Such intrusive recollections are often triggered by reminders associated with the trauma. We examined the impact of exposure to a trauma reminder (under water trauma (UWT)) on the activation of the basolateral amygdala (BLA), dorsal and VH. Rats were exposed to UWT and 24 h later were re-exposed to the context of the trauma. Phosphorylation of the extracellular signal-regulated kinase (ERK) was used as a marker for level of activation of these regions. Significant increase in ERK activation was found in the VH and BLA. Such pattern of activation was not found in animals exposed only to the trauma or in animals exposed only to the trauma reminder. Additionally, the dissociative pattern of activation of the VH sub-regions positively correlated with the activation of the BLA. Our findings suggest a specific pattern of neural activation during recollection of a trauma reminder, with a unique contribution of the VH. Measured 24 h after the exposure to the traumatic experience, the current findings relate to relatively early stages of traumatic memory consolidation. Understanding the neural mechanisms underlying these initial stages may contribute to developing intervention strategies that could reduce the risk of eventually developing PTSD. Frontiers Media S.A. 2014-01-29 /pmc/articles/PMC3905214/ /pubmed/24523683 http://dx.doi.org/10.3389/fnbeh.2014.00018 Text en Copyright © 2013 Ritov, Ardi and Richter-Levin. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Ritov, Gilad
Ardi, Ziv
Richter-Levin, Gal
Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma
title Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma
title_full Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma
title_fullStr Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma
title_full_unstemmed Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma
title_short Differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma
title_sort differential activation of amygdala, dorsal and ventral hippocampus following an exposure to a reminder of underwater trauma
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905214/
https://www.ncbi.nlm.nih.gov/pubmed/24523683
http://dx.doi.org/10.3389/fnbeh.2014.00018
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