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Ultrasonically encoded wavefront shaping for focusing into random media

Phase distortions due to scattering in random media restrict optical focusing beyond one transport mean free path. However, scattering can be compensated for by applying a correction to the illumination wavefront using spatial light modulators. One method of obtaining the wavefront correction is by...

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Detalles Bibliográficos
Autores principales: Tay, Jian Wei, Lai, Puxiang, Suzuki, Yuta, Wang, Lihong V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905274/
https://www.ncbi.nlm.nih.gov/pubmed/24472822
http://dx.doi.org/10.1038/srep03918
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author Tay, Jian Wei
Lai, Puxiang
Suzuki, Yuta
Wang, Lihong V.
author_facet Tay, Jian Wei
Lai, Puxiang
Suzuki, Yuta
Wang, Lihong V.
author_sort Tay, Jian Wei
collection PubMed
description Phase distortions due to scattering in random media restrict optical focusing beyond one transport mean free path. However, scattering can be compensated for by applying a correction to the illumination wavefront using spatial light modulators. One method of obtaining the wavefront correction is by iterative determination using an optimization algorithm. In the past, obtaining a feedback signal required either direct optical access to the target region, or invasive embedding of molecular probes within the random media. Here, we propose using ultrasonically encoded light as feedback to guide the optimization dynamically and non-invasively. In our proof-of-principle demonstration, diffuse light was refocused to the ultrasound focal zone, with a focus-to-background ratio of more than one order of magnitude after 600 iterations. With further improvements, especially in optimization speed, the proposed method should find broad applications in deep tissue optical imaging and therapy.
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spelling pubmed-39052742014-01-29 Ultrasonically encoded wavefront shaping for focusing into random media Tay, Jian Wei Lai, Puxiang Suzuki, Yuta Wang, Lihong V. Sci Rep Article Phase distortions due to scattering in random media restrict optical focusing beyond one transport mean free path. However, scattering can be compensated for by applying a correction to the illumination wavefront using spatial light modulators. One method of obtaining the wavefront correction is by iterative determination using an optimization algorithm. In the past, obtaining a feedback signal required either direct optical access to the target region, or invasive embedding of molecular probes within the random media. Here, we propose using ultrasonically encoded light as feedback to guide the optimization dynamically and non-invasively. In our proof-of-principle demonstration, diffuse light was refocused to the ultrasound focal zone, with a focus-to-background ratio of more than one order of magnitude after 600 iterations. With further improvements, especially in optimization speed, the proposed method should find broad applications in deep tissue optical imaging and therapy. Nature Publishing Group 2014-01-29 /pmc/articles/PMC3905274/ /pubmed/24472822 http://dx.doi.org/10.1038/srep03918 Text en Copyright © 2014, Macmillan Publishers Limited. All rights reserved http://creativecommons.org/licenses/by-nc-nd/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/3.0/
spellingShingle Article
Tay, Jian Wei
Lai, Puxiang
Suzuki, Yuta
Wang, Lihong V.
Ultrasonically encoded wavefront shaping for focusing into random media
title Ultrasonically encoded wavefront shaping for focusing into random media
title_full Ultrasonically encoded wavefront shaping for focusing into random media
title_fullStr Ultrasonically encoded wavefront shaping for focusing into random media
title_full_unstemmed Ultrasonically encoded wavefront shaping for focusing into random media
title_short Ultrasonically encoded wavefront shaping for focusing into random media
title_sort ultrasonically encoded wavefront shaping for focusing into random media
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905274/
https://www.ncbi.nlm.nih.gov/pubmed/24472822
http://dx.doi.org/10.1038/srep03918
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