Results of treatment of acute myeloid leukemia in central part of Iran

BACKGROUND: Acute myeloid leukemia (AML) is the most common type of leukemia. In this study, outcome of intensive chemotherapy in patients treated in a large urban public university hospital in a developing country was investigated. MATERIALS AND METHODS: The records of all patients treated for AML...

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Detalles Bibliográficos
Autores principales: Ashrafi, Farzaneh, Shahnazari, Razieh, Samimi, Mojgan Alam, Mehrzad, Valliollah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2013
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905340/
https://www.ncbi.nlm.nih.gov/pubmed/24516851
http://dx.doi.org/10.4103/2277-9175.114194
Descripción
Sumario:BACKGROUND: Acute myeloid leukemia (AML) is the most common type of leukemia. In this study, outcome of intensive chemotherapy in patients treated in a large urban public university hospital in a developing country was investigated. MATERIALS AND METHODS: The records of all patients treated for AML with 3 + 7 protocol from 2002 to 2010 were analyzed. RESULTS: Among 95 patients, 34 (35.8%) were female and 61 (64.2%) were male patients. Patients’ median age was 37 years, ranging 15-68 years. Complete remission (CR) was observed in 56 (58.9%) of patients treated with this protocol. Median overall survival was 13 months (95% CI: 8.8-17.1 months). The 1-year AML survival rate was 51%, and 2-year survival rate was 26%. CONCLUSION: Our study shows that in our center in Iran, CR rates and median overall survival rates after induction chemotherapy are less than developed countries.

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