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Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines
HIV/AIDS is an important public health problem globally. An affordable, easy-to-deliver and protective HIV vaccine is therefore required to curb the pandemic from spreading further. Recombinant Salmonella bacteria can be harnessed to vector HIV antigens or DNA vaccines to the immune system for induc...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Open
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905348/ https://www.ncbi.nlm.nih.gov/pubmed/24478808 http://dx.doi.org/10.2174/1874357901307010121 |
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author | Chin’ombe, Nyasha Ruhanya, Vurayai |
author_facet | Chin’ombe, Nyasha Ruhanya, Vurayai |
author_sort | Chin’ombe, Nyasha |
collection | PubMed |
description | HIV/AIDS is an important public health problem globally. An affordable, easy-to-deliver and protective HIV vaccine is therefore required to curb the pandemic from spreading further. Recombinant Salmonella bacteria can be harnessed to vector HIV antigens or DNA vaccines to the immune system for induction of specific protective immunity. These are capable of activating the innate, humoral and cellular immune responses at both mucosal and systemic compartments. Several studies have already demonstrated the utility of live recombinant Salmonella in delivering expressed foreign antigens as well as DNA vaccines to the host immune system. This review gives an overview of the studies in which recombinant Salmonella bacteria were used to vector HIV/AIDS antigens and DNA vaccines. Most of the recombinant Salmonella-based HIV/AIDS vaccines developed so far have only been tested in animals (mainly mice) and are yet to reach human trials. |
format | Online Article Text |
id | pubmed-3905348 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Bentham Open |
record_format | MEDLINE/PubMed |
spelling | pubmed-39053482014-01-29 Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines Chin’ombe, Nyasha Ruhanya, Vurayai Open Virol J Article HIV/AIDS is an important public health problem globally. An affordable, easy-to-deliver and protective HIV vaccine is therefore required to curb the pandemic from spreading further. Recombinant Salmonella bacteria can be harnessed to vector HIV antigens or DNA vaccines to the immune system for induction of specific protective immunity. These are capable of activating the innate, humoral and cellular immune responses at both mucosal and systemic compartments. Several studies have already demonstrated the utility of live recombinant Salmonella in delivering expressed foreign antigens as well as DNA vaccines to the host immune system. This review gives an overview of the studies in which recombinant Salmonella bacteria were used to vector HIV/AIDS antigens and DNA vaccines. Most of the recombinant Salmonella-based HIV/AIDS vaccines developed so far have only been tested in animals (mainly mice) and are yet to reach human trials. Bentham Open 2013-12-30 /pmc/articles/PMC3905348/ /pubmed/24478808 http://dx.doi.org/10.2174/1874357901307010121 Text en © Chin’ombe and Ruhanya; Licensee Bentham Open.. http: //creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http: //creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. |
spellingShingle | Article Chin’ombe, Nyasha Ruhanya, Vurayai Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines |
title | Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines |
title_full | Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines |
title_fullStr | Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines |
title_full_unstemmed | Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines |
title_short | Recombinant Salmonella Bacteria Vectoring HIV/AIDS Vaccines |
title_sort | recombinant salmonella bacteria vectoring hiv/aids vaccines |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905348/ https://www.ncbi.nlm.nih.gov/pubmed/24478808 http://dx.doi.org/10.2174/1874357901307010121 |
work_keys_str_mv | AT chinombenyasha recombinantsalmonellabacteriavectoringhivaidsvaccines AT ruhanyavurayai recombinantsalmonellabacteriavectoringhivaidsvaccines |