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PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population
BACKGROUND: The PPAR α and PPAR γ are the key messengers responsible for the translation of nutritional stimuli into changes for the expression of genes, particularly genes involved in lipid metabolism. However, the associations between PPAR α / γ polymorphisms and lipid serum levels in the general...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905651/ https://www.ncbi.nlm.nih.gov/pubmed/24460649 http://dx.doi.org/10.1186/1476-511X-13-23 |
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author | Gu, Shu-Jun Guo, Zhi-Rong Zhou, Zheng-Yuan Hu, Xiao-Shu Wu, Ming |
author_facet | Gu, Shu-Jun Guo, Zhi-Rong Zhou, Zheng-Yuan Hu, Xiao-Shu Wu, Ming |
author_sort | Gu, Shu-Jun |
collection | PubMed |
description | BACKGROUND: The PPAR α and PPAR γ are the key messengers responsible for the translation of nutritional stimuli into changes for the expression of genes, particularly genes involved in lipid metabolism. However, the associations between PPAR α / γ polymorphisms and lipid serum levels in the general population were rarely studied, and the conclusions were conflicting. The objective was to investigate the associations of the PPAR α and PPAR γ polymorphisms with dyslipidemia. METHODS: 820 subjects were randomly selected from the Prevention of Multiple Metabolic Disorders and MS in Jiangsu Province cohort populations. The logistic regression model was used to examine the association between these polymorphisms and dyslipidemia. SNPstats was used to explore the haplotype association analyses. RESULTS: In the codominant and log-additive models, rs1800206, rs1805192 and rs3856806 were all associated with dyslipidemia (P < 0.005). When the most common haplotype L-G (established by rs1800206, rs4253778) was treated as the reference group, the V-G haplotype was associated with dyslipidemia (P < 0.001), higher TC and TG levels (P < 0.01). Moreover, when compared to Pro-C haplotype (established by rs1805192, rs3856806), the Pro-T, Ala-C, Ala-T haplotypes were associated with dyslipidemia (p < 0.001). A-T haplotype was associated with higher TC levels, (p < 0.01), and the P-T, A-C, A-T haplotypes were associated with higher TG levels (p < 0.01). CONCLUSIONS: PPAR α and PPAR γ polymorphisms and haplotypes may be the genetic risk factors for dyslipidemia. |
format | Online Article Text |
id | pubmed-3905651 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-39056512014-01-30 PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population Gu, Shu-Jun Guo, Zhi-Rong Zhou, Zheng-Yuan Hu, Xiao-Shu Wu, Ming Lipids Health Dis Research BACKGROUND: The PPAR α and PPAR γ are the key messengers responsible for the translation of nutritional stimuli into changes for the expression of genes, particularly genes involved in lipid metabolism. However, the associations between PPAR α / γ polymorphisms and lipid serum levels in the general population were rarely studied, and the conclusions were conflicting. The objective was to investigate the associations of the PPAR α and PPAR γ polymorphisms with dyslipidemia. METHODS: 820 subjects were randomly selected from the Prevention of Multiple Metabolic Disorders and MS in Jiangsu Province cohort populations. The logistic regression model was used to examine the association between these polymorphisms and dyslipidemia. SNPstats was used to explore the haplotype association analyses. RESULTS: In the codominant and log-additive models, rs1800206, rs1805192 and rs3856806 were all associated with dyslipidemia (P < 0.005). When the most common haplotype L-G (established by rs1800206, rs4253778) was treated as the reference group, the V-G haplotype was associated with dyslipidemia (P < 0.001), higher TC and TG levels (P < 0.01). Moreover, when compared to Pro-C haplotype (established by rs1805192, rs3856806), the Pro-T, Ala-C, Ala-T haplotypes were associated with dyslipidemia (p < 0.001). A-T haplotype was associated with higher TC levels, (p < 0.01), and the P-T, A-C, A-T haplotypes were associated with higher TG levels (p < 0.01). CONCLUSIONS: PPAR α and PPAR γ polymorphisms and haplotypes may be the genetic risk factors for dyslipidemia. BioMed Central 2014-01-26 /pmc/articles/PMC3905651/ /pubmed/24460649 http://dx.doi.org/10.1186/1476-511X-13-23 Text en Copyright © 2014 Gu et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Gu, Shu-Jun Guo, Zhi-Rong Zhou, Zheng-Yuan Hu, Xiao-Shu Wu, Ming PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population |
title | PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population |
title_full | PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population |
title_fullStr | PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population |
title_full_unstemmed | PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population |
title_short | PPAR α and PPAR γ Polymorphisms as risk factors for Dyslipidemia in a Chinese han population |
title_sort | ppar α and ppar γ polymorphisms as risk factors for dyslipidemia in a chinese han population |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905651/ https://www.ncbi.nlm.nih.gov/pubmed/24460649 http://dx.doi.org/10.1186/1476-511X-13-23 |
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