Passive immunization of macaques with polyclonal anti-SHIV IgG against a heterologous tier 2 SHIV: outcome depends on IgG dose

BACKGROUND: A key goal for HIV-1 envelope immunogen design is the induction of cross-reactive neutralizing antibodies (nAbs). As AIDS vaccine recipients will not be exposed to strains exactly matching any immunogens due to multiple HIV-1 quasispecies circulating in the human population worldwide, he...

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Detalles Bibliográficos
Autores principales: Sholukh, Anton M, Byrareddy, Siddappa N, Shanmuganathan, Vivekanandan, Hemashettar, Girish, Lakhashe, Samir K, Rasmussen, Robert A, Watkins, Jennifer D, Vyas, Hemant K, Thorat, Swati, Brandstoetter, Tania, Mukhtar, Muhammad M, Yoon, John K, Novembre, Francis J, Villinger, Francois, Landucci, Gary, Forthal, Donald N, Ratcliffe, Sarah, Tuero, Iskra, Robert-Guroff, Marjorie, Polonis, Victoria R, Bilska, Miroslawa, Montefiori, David C, Johnson, Welkin E, Ertl, Hildegund C, Ruprecht, Ruth M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905655/
https://www.ncbi.nlm.nih.gov/pubmed/24444350
http://dx.doi.org/10.1186/1742-4690-11-8

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