General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination

This introductory paper gathers general considerations on the biosafety of virus-derived vectors that are used in human gene therapy and/or vaccination. The importance to assess the potential risks for human health and the environment related to the use of genetically modified organisms (GMO) in thi...

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Autores principales: Baldo, Aline, van den Akker, Eric, Bergmans, Hans E., Lim, Filip, Pauwels, Katia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905712/
https://www.ncbi.nlm.nih.gov/pubmed/24195604
http://dx.doi.org/10.2174/15665232113136660005
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author Baldo, Aline
van den Akker, Eric
Bergmans, Hans E.
Lim, Filip
Pauwels, Katia
author_facet Baldo, Aline
van den Akker, Eric
Bergmans, Hans E.
Lim, Filip
Pauwels, Katia
author_sort Baldo, Aline
collection PubMed
description This introductory paper gathers general considerations on the biosafety of virus-derived vectors that are used in human gene therapy and/or vaccination. The importance to assess the potential risks for human health and the environment related to the use of genetically modified organisms (GMO) in this case genetically modified viral vectors is highlighted by several examples. This environmental risk assessment is one of the requirements within the European regulatory framework covering the conduct of clinical trials using GMO. Risk assessment methodologies for the environmental risk assessment of genetically modified virus-derived vectors have been developed.
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spelling pubmed-39057122014-01-29 General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination Baldo, Aline van den Akker, Eric Bergmans, Hans E. Lim, Filip Pauwels, Katia Curr Gene Ther Article This introductory paper gathers general considerations on the biosafety of virus-derived vectors that are used in human gene therapy and/or vaccination. The importance to assess the potential risks for human health and the environment related to the use of genetically modified organisms (GMO) in this case genetically modified viral vectors is highlighted by several examples. This environmental risk assessment is one of the requirements within the European regulatory framework covering the conduct of clinical trials using GMO. Risk assessment methodologies for the environmental risk assessment of genetically modified virus-derived vectors have been developed. Bentham Science Publishers 2013-04 2013-04 /pmc/articles/PMC3905712/ /pubmed/24195604 http://dx.doi.org/10.2174/15665232113136660005 Text en © 2013 Bentham Science Publishers http://creativecommons.org/licenses/by-nc/3.0/ This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Baldo, Aline
van den Akker, Eric
Bergmans, Hans E.
Lim, Filip
Pauwels, Katia
General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination
title General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination
title_full General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination
title_fullStr General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination
title_full_unstemmed General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination
title_short General Considerations on the Biosafety of Virus-derived Vectors Used in Gene Therapy and Vaccination
title_sort general considerations on the biosafety of virus-derived vectors used in gene therapy and vaccination
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905712/
https://www.ncbi.nlm.nih.gov/pubmed/24195604
http://dx.doi.org/10.2174/15665232113136660005
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