A rare functional cardioprotective APOC3 variant has risen in frequency in distinct population isolates

Isolated populations can empower the identification of rare variation associated with complex traits through next generation association studies, but the generalizability of such findings remains unknown. Here we genotype 1,267 individuals from a Greek population isolate on the Illumina HumanExome B...

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Detalles Bibliográficos
Autores principales: Tachmazidou, Ioanna, Dedoussis, George, Southam, Lorraine, Farmaki, Aliki-Eleni, Ritchie, Graham R. S., Xifara, Dionysia K., Matchan, Angela, Hatzikotoulas, Konstantinos, Rayner, Nigel W., Chen, Yuan, Pollin, Toni I., O’Connell, Jeffrey R., Yerges-Armstrong, Laura M., Kiagiadaki, Chrysoula, Panoutsopoulou, Kalliope, Schwartzentruber, Jeremy, Moutsianas, Loukas, Tsafantakis, Emmanouil, Tyler-Smith, Chris, McVean, Gil, Xue, Yali, Zeggini, Eleftheria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2013
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905724/
https://www.ncbi.nlm.nih.gov/pubmed/24343240
http://dx.doi.org/10.1038/ncomms3872

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