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Mesalazine-induced renal calculi

Patient: Female, 32 Final Diagnosis: Renal colic Symptoms: Acute colic pain • macrohematuria Medication: Mesalazine Clinical Procedure: CT scan of urinary tract • cystoscopy • gynecological consultation • stone analysis Specialty: Gastroenterology and Hepatology • Clinical Pharmacology OBJECTIVE: Un...

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Detalles Bibliográficos
Autores principales: Jacobsson, Henrik, Eriksen, Jaran, Karlén, Per
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905811/
https://www.ncbi.nlm.nih.gov/pubmed/24478817
http://dx.doi.org/10.12659/AJCR.889719
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author Jacobsson, Henrik
Eriksen, Jaran
Karlén, Per
author_facet Jacobsson, Henrik
Eriksen, Jaran
Karlén, Per
author_sort Jacobsson, Henrik
collection PubMed
description Patient: Female, 32 Final Diagnosis: Renal colic Symptoms: Acute colic pain • macrohematuria Medication: Mesalazine Clinical Procedure: CT scan of urinary tract • cystoscopy • gynecological consultation • stone analysis Specialty: Gastroenterology and Hepatology • Clinical Pharmacology OBJECTIVE: Unexpected drug reaction BACKGROUND: Mesalazine, a 5-aminosalicylic acid compound, is one of the cornerstones in modern treatment regimens of ulcerative colitis. It is generally well tolerated, although adverse reactions such as nephrotoxicity, perimyocarditis, and pancreatitis have been reported. CASE REPORT: We report the case of a 32-year-old woman with colitis who developed recurrent episodes of renal colic after introduction of mesalazine to her treatment. Biochemical analysis of the stones showed that they were composed of crystalized drug material. CONCLUSIONS: To our knowledge this is the first report of mesalazine precipitation in the urinary tract. We believe that it is vital for physicians to recognize this potentially severe adverse effect in the use of this treatment.
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spelling pubmed-39058112014-01-29 Mesalazine-induced renal calculi Jacobsson, Henrik Eriksen, Jaran Karlén, Per Am J Case Rep Articles Patient: Female, 32 Final Diagnosis: Renal colic Symptoms: Acute colic pain • macrohematuria Medication: Mesalazine Clinical Procedure: CT scan of urinary tract • cystoscopy • gynecological consultation • stone analysis Specialty: Gastroenterology and Hepatology • Clinical Pharmacology OBJECTIVE: Unexpected drug reaction BACKGROUND: Mesalazine, a 5-aminosalicylic acid compound, is one of the cornerstones in modern treatment regimens of ulcerative colitis. It is generally well tolerated, although adverse reactions such as nephrotoxicity, perimyocarditis, and pancreatitis have been reported. CASE REPORT: We report the case of a 32-year-old woman with colitis who developed recurrent episodes of renal colic after introduction of mesalazine to her treatment. Biochemical analysis of the stones showed that they were composed of crystalized drug material. CONCLUSIONS: To our knowledge this is the first report of mesalazine precipitation in the urinary tract. We believe that it is vital for physicians to recognize this potentially severe adverse effect in the use of this treatment. International Scientific Literature, Inc. 2013-12-23 /pmc/articles/PMC3905811/ /pubmed/24478817 http://dx.doi.org/10.12659/AJCR.889719 Text en © Am J Case Rep, 2014 This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported License
spellingShingle Articles
Jacobsson, Henrik
Eriksen, Jaran
Karlén, Per
Mesalazine-induced renal calculi
title Mesalazine-induced renal calculi
title_full Mesalazine-induced renal calculi
title_fullStr Mesalazine-induced renal calculi
title_full_unstemmed Mesalazine-induced renal calculi
title_short Mesalazine-induced renal calculi
title_sort mesalazine-induced renal calculi
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905811/
https://www.ncbi.nlm.nih.gov/pubmed/24478817
http://dx.doi.org/10.12659/AJCR.889719
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