Phosphorylated (pT371)TRF1 is recruited to sites of DNA damage to facilitate homologous recombination and checkpoint activation

TRF1, a duplex telomeric DNA-binding protein, plays an important role in telomere metabolism. We have previously reported that a fraction of endogenous TRF1 can stably exist free of telomere chromatin when it is phosphorylated at T371 by Cdk1; however, the role of this telomere-free (pT371)TRF1 has...

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Detalles Bibliográficos
Autores principales: McKerlie, Megan, Walker, John R., Mitchell, Taylor R. H., Wilson, Florence R., Zhu, Xu-Dong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905873/
https://www.ncbi.nlm.nih.gov/pubmed/23997120
http://dx.doi.org/10.1093/nar/gkt775

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