Antisense transcripts enhanced by camptothecin at divergent CpG-island promoters associated with bursts of topoisomerase I-DNA cleavage complex and R-loop formation

DNA Topoisomerase I (Top1) is required to relax DNA supercoils generated by RNA polymerases (RNAPs). Top1 is inhibited with high specificity by camptothecin (CPT), an effective anticancer agent, and by oxidative base damage and ribonucleotides in DNA strands, resulting into Top1-DNA cleavage complex...

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Detalles Bibliográficos
Autores principales: Marinello, Jessica, Chillemi, Giovanni, Bueno, Susana, Manzo, Stefano G., Capranico, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Gene Regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905886/
https://www.ncbi.nlm.nih.gov/pubmed/23999093
http://dx.doi.org/10.1093/nar/gkt778

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905886/
https://www.ncbi.nlm.nih.gov/pubmed/23999093
http://dx.doi.org/10.1093/nar/gkt778

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