Catalytic mechanism of α-phosphate attack in dUTPase is revealed by X-ray crystallographic snapshots of distinct intermediates, (31)P-NMR spectroscopy and reaction path modelling

Enzymatic synthesis and hydrolysis of nucleoside phosphate compounds play a key role in various biological pathways, like signal transduction, DNA synthesis and metabolism. Although these processes have been studied extensively, numerous key issues regarding the chemical pathway and atomic movements...

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Detalles Bibliográficos
Autores principales: Barabás, Orsolya, Németh, Veronika, Bodor, Andrea, Perczel, András, Rosta, Edina, Kele, Zoltán, Zagyva, Imre, Szabadka, Zoltán, Grolmusz, Vince I., Wilmanns, Matthias, Vértessy, Beáta G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905902/
https://www.ncbi.nlm.nih.gov/pubmed/23982515
http://dx.doi.org/10.1093/nar/gkt756

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