Multidimensional Single-Cell Analysis of BCR Signaling Reveals Proximal Activation Defect As a Hallmark of Chronic Lymphocytic Leukemia B Cells

PURPOSE: Chronic Lymphocytic Leukemia (CLL) is defined by a perturbed B-cell receptor-mediated signaling machinery. We aimed to model differential signaling behavior between B cells from CLL and healthy individuals to pinpoint modes of dysregulation. EXPERIMENTAL DESIGN: We developed an experimental...

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Detalles Bibliográficos
Autores principales: Palomba, M. Lia, Piersanti, Kelly, Ziegler, Carly G. K., Decker, Hugo, Cotari, Jesse W., Bantilan, Kurt, Rijo, Ivelise, Gardner, Jeff R., Heaney, Mark, Bemis, Debra, Balderas, Robert, Malek, Sami N., Seymour, Erlene, Zelenetz, Andrew D., van den Brink, Marcel R. M., Altan-Bonnet, Grégoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906024/
https://www.ncbi.nlm.nih.gov/pubmed/24489640
http://dx.doi.org/10.1371/journal.pone.0079987

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