Impact of ABCB1 and CYP2B6 Genetic Polymorphisms on Methadone Metabolism, Dose and Treatment Response in Patients with Opioid Addiction: A Systematic Review and Meta-Analysis

BACKGROUND: Genetic variability may influence methadone metabolism, dose requirements, and risk of relapse. OBJECTIVES: To determine whether the CYP2B6*6 or ABCB1 (rs1045642) polymorphisms are associated with variation in methadone response (plasma concentration, dose, or response to treatment). MET...

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Detalles Bibliográficos
Autores principales: Dennis, Brittany B., Bawor, Monica, Thabane, Lehana, Sohani, Zahra, Samaan, Zainab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906028/
https://www.ncbi.nlm.nih.gov/pubmed/24489693
http://dx.doi.org/10.1371/journal.pone.0086114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906028/
https://www.ncbi.nlm.nih.gov/pubmed/24489693
http://dx.doi.org/10.1371/journal.pone.0086114

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