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Inducible, Dose-Adjustable and Time-Restricted Reconstitution of Stat1 Deficiency In Vivo
Signal transducer and activator of transcription (STAT) 1 is a key player in interferon (IFN) signaling, essential in mediating host defense against viruses and other pathogens. STAT1 levels are tightly regulated and loss- or gain-of-function mutations in mice and men lead to severe diseases. We hav...
| Autores principales: | , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906053/ https://www.ncbi.nlm.nih.gov/pubmed/24489749 http://dx.doi.org/10.1371/journal.pone.0086608 |