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Model Steatogenic Compounds (Amiodarone, Valproic Acid, and Tetracycline) Alter Lipid Metabolism by Different Mechanisms in Mouse Liver Slices
Although drug induced steatosis represents a mild type of hepatotoxicity it can progress into more severe non-alcoholic steatohepatitis. Current models used for safety assessment in drug development and chemical risk assessment do not accurately predict steatosis in humans. Therefore, new models nee...
Autores principales: | Szalowska, Ewa, van der Burg, Bart, Man, Hai-Yen, Hendriksen, Peter J. M., Peijnenburg, Ad A. C. M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906077/ https://www.ncbi.nlm.nih.gov/pubmed/24489787 http://dx.doi.org/10.1371/journal.pone.0086795 |
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