HIV-1 Nef Down-Modulates C-C and C-X-C Chemokine Receptors via Ubiquitin and Ubiquitin-Independent Mechanism

Human and Simian Immunodeficiency virus (HIV-1, HIV-2, and SIV) encode an accessory protein, Nef, which is a pathogenesis and virulence factor. Nef is a multivalent adapter that dysregulates the trafficking of many immune cell receptors, including chemokine receptors (CKRs). Physiological endocytic...

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Detalles Bibliográficos
Autores principales: Chandrasekaran, Prabha, Moore, Victoria, Buckley, Monica, Spurrier, Joshua, Kehrl, John H., Venkatesan, Sundararajan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906104/
https://www.ncbi.nlm.nih.gov/pubmed/24489825
http://dx.doi.org/10.1371/journal.pone.0086998

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906104/
https://www.ncbi.nlm.nih.gov/pubmed/24489825
http://dx.doi.org/10.1371/journal.pone.0086998

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