brca2 and tp53 Collaborate in Tumorigenesis in Zebrafish

Germline mutations in the tumor suppressor genes BRCA2 and TP53 significantly influence human cancer risk, and cancers from humans who inherit one mutant allele for BRCA2 or TP53 often display loss of the wildtype allele. In addition, BRCA2-associated cancers often exhibit mutations in TP53. To dete...

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Detalles Bibliográficos
Autores principales: Shive, Heather R., West, Robert R., Embree, Lisa J., Golden, Champa D., Hickstein, Dennis D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906131/
https://www.ncbi.nlm.nih.gov/pubmed/24489863
http://dx.doi.org/10.1371/journal.pone.0087177

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906131/
https://www.ncbi.nlm.nih.gov/pubmed/24489863
http://dx.doi.org/10.1371/journal.pone.0087177

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