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Chemical and Genetic Validation of the Statin Drug Target to Treat the Helminth Disease, Schistosomiasis

The mevalonate pathway is essential in eukaryotes and responsible for a diversity of fundamental synthetic activities. 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) is the rate-limiting enzyme in the pathway and is targeted by the ubiquitous statin drugs to treat hypercholesterolemia. Indep...

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Detalles Bibliográficos
Autores principales:	Rojo-Arreola, Liliana, Long, Thavy, Asarnow, Dan, Suzuki, Brian M., Singh, Rahul, Caffrey, Conor R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906178/ https://www.ncbi.nlm.nih.gov/pubmed/24489942 http://dx.doi.org/10.1371/journal.pone.0087594

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