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An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes

The insect immune response demonstrates a number of structural and functional similarities to the innate immune system of mammals. As a result of these conserved features insects have become popular choices for evaluating the virulence of microbial pathogens or for assessing the efficacy of antimicr...

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Detalles Bibliográficos
Autores principales: Browne, Niall, Heelan, Michelle, Kavanagh, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906293/
https://www.ncbi.nlm.nih.gov/pubmed/23921374
http://dx.doi.org/10.4161/viru.25906
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author Browne, Niall
Heelan, Michelle
Kavanagh, Kevin
author_facet Browne, Niall
Heelan, Michelle
Kavanagh, Kevin
author_sort Browne, Niall
collection PubMed
description The insect immune response demonstrates a number of structural and functional similarities to the innate immune system of mammals. As a result of these conserved features insects have become popular choices for evaluating the virulence of microbial pathogens or for assessing the efficacy of antimicrobial agents and give results which are comparable to those that can be obtained using mammals. Analysis of the cellular component of the insect and mammalian immune systems demonstrates many similarities. Insect hemocytes recognize pathogens and phagocytose material in a similar manner to neutrophils. The killing of ingested microbes is achieved in both cell types by the production of superoxide and by the release of enzymes in the process of degranulation. Insect hemocytes and mammalian neutrophils are sensitive to the same inhibitors. This review highlights the strong similarities between the phagocytic cells of both groups of animals and demonstrates the potential benefits of using selected insects as in vivo screening systems.
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spelling pubmed-39062932014-02-05 An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes Browne, Niall Heelan, Michelle Kavanagh, Kevin Virulence Review The insect immune response demonstrates a number of structural and functional similarities to the innate immune system of mammals. As a result of these conserved features insects have become popular choices for evaluating the virulence of microbial pathogens or for assessing the efficacy of antimicrobial agents and give results which are comparable to those that can be obtained using mammals. Analysis of the cellular component of the insect and mammalian immune systems demonstrates many similarities. Insect hemocytes recognize pathogens and phagocytose material in a similar manner to neutrophils. The killing of ingested microbes is achieved in both cell types by the production of superoxide and by the release of enzymes in the process of degranulation. Insect hemocytes and mammalian neutrophils are sensitive to the same inhibitors. This review highlights the strong similarities between the phagocytic cells of both groups of animals and demonstrates the potential benefits of using selected insects as in vivo screening systems. Landes Bioscience 2013-10-01 2013-08-06 /pmc/articles/PMC3906293/ /pubmed/23921374 http://dx.doi.org/10.4161/viru.25906 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Browne, Niall
Heelan, Michelle
Kavanagh, Kevin
An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes
title An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes
title_full An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes
title_fullStr An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes
title_full_unstemmed An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes
title_short An analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes
title_sort analysis of the structural and functional similarities of insect hemocytes and mammalian phagocytes
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906293/
https://www.ncbi.nlm.nih.gov/pubmed/23921374
http://dx.doi.org/10.4161/viru.25906
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