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Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense?

The integrated US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has made great strides in strategic preparedness and response capabilities. There have been numerous advances in planning, biothreat countermeasure development, licensure, manufacturing, stockpiling and deployment....

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Detalles Bibliográficos
Autores principales: De Groot, Anne S, Einck, Leo, Moise, Leonard, Chambers, Michael, Ballantyne, John, Malone, Robert W, Ardito, Matthew, Martin, William
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906351/
https://www.ncbi.nlm.nih.gov/pubmed/23877094
http://dx.doi.org/10.4161/hv.25611
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author De Groot, Anne S
Einck, Leo
Moise, Leonard
Chambers, Michael
Ballantyne, John
Malone, Robert W
Ardito, Matthew
Martin, William
author_facet De Groot, Anne S
Einck, Leo
Moise, Leonard
Chambers, Michael
Ballantyne, John
Malone, Robert W
Ardito, Matthew
Martin, William
author_sort De Groot, Anne S
collection PubMed
description The integrated US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has made great strides in strategic preparedness and response capabilities. There have been numerous advances in planning, biothreat countermeasure development, licensure, manufacturing, stockpiling and deployment. Increased biodefense surveillance capability has dramatically improved, while new tools and increased awareness have fostered rapid identification of new potential public health pathogens. Unfortunately, structural delays in vaccine design, development, manufacture, clinical testing and licensure processes remain significant obstacles to an effective national biodefense rapid response capability. This is particularly true for the very real threat of “novel pathogens” such as the avian-origin influenzas H7N9 and H5N1, and new coronaviruses such as hCoV-EMC. Conventional approaches to vaccine development, production, clinical testing and licensure are incompatible with the prompt deployment needed for an effective public health response. An alternative approach, proposed here, is to apply computational vaccine design tools and rapid production technologies that now make it possible to engineer vaccines for novel emerging pathogen and WMD biowarfare agent countermeasures in record time. These new tools have the potential to significantly reduce the time needed to design string-of-epitope vaccines for previously unknown pathogens. The design process—from genome to gene sequence, ready to insert in a DNA plasmid—can now be accomplished in less than 24 h. While these vaccines are by no means “standard,” the need for innovation in the vaccine design and production process is great. Should such vaccines be developed, their 60-d start-to-finish timeline would represent a 2-fold faster response than the current standard.
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spelling pubmed-39063512014-02-04 Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense? De Groot, Anne S Einck, Leo Moise, Leonard Chambers, Michael Ballantyne, John Malone, Robert W Ardito, Matthew Martin, William Hum Vaccin Immunother Commentary The integrated US Public Health Emergency Medical Countermeasures Enterprise (PHEMCE) has made great strides in strategic preparedness and response capabilities. There have been numerous advances in planning, biothreat countermeasure development, licensure, manufacturing, stockpiling and deployment. Increased biodefense surveillance capability has dramatically improved, while new tools and increased awareness have fostered rapid identification of new potential public health pathogens. Unfortunately, structural delays in vaccine design, development, manufacture, clinical testing and licensure processes remain significant obstacles to an effective national biodefense rapid response capability. This is particularly true for the very real threat of “novel pathogens” such as the avian-origin influenzas H7N9 and H5N1, and new coronaviruses such as hCoV-EMC. Conventional approaches to vaccine development, production, clinical testing and licensure are incompatible with the prompt deployment needed for an effective public health response. An alternative approach, proposed here, is to apply computational vaccine design tools and rapid production technologies that now make it possible to engineer vaccines for novel emerging pathogen and WMD biowarfare agent countermeasures in record time. These new tools have the potential to significantly reduce the time needed to design string-of-epitope vaccines for previously unknown pathogens. The design process—from genome to gene sequence, ready to insert in a DNA plasmid—can now be accomplished in less than 24 h. While these vaccines are by no means “standard,” the need for innovation in the vaccine design and production process is great. Should such vaccines be developed, their 60-d start-to-finish timeline would represent a 2-fold faster response than the current standard. Landes Bioscience 2013-09-01 2013-07-22 /pmc/articles/PMC3906351/ /pubmed/23877094 http://dx.doi.org/10.4161/hv.25611 Text en Copyright © 2013 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Commentary
De Groot, Anne S
Einck, Leo
Moise, Leonard
Chambers, Michael
Ballantyne, John
Malone, Robert W
Ardito, Matthew
Martin, William
Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense?
title Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense?
title_full Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense?
title_fullStr Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense?
title_full_unstemmed Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense?
title_short Making vaccines “on demand”: A potential solution for emerging pathogens and biodefense?
title_sort making vaccines “on demand”: a potential solution for emerging pathogens and biodefense?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906351/
https://www.ncbi.nlm.nih.gov/pubmed/23877094
http://dx.doi.org/10.4161/hv.25611
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