Cargando…
Trials and Tribulations with VH Replacement
VH replacement (VHR) is a type of antibody gene rearrangement in which an upstream heavy chain variable gene segment (VH) invades a pre-existing rearrangement (VDJ). In this Hypothesis and Theory article, we begin by reviewing the mechanism of VHR, its developmental timing and its potential biologic...
Autores principales: | Meng, Wenzhao, Jayaraman, Sahana, Zhang, Bochao, Schwartz, Gregory W., Daber, Robert D., Hershberg, Uri, Garfall, Alfred L., Carlson, Christopher S., Luning Prak, Eline T. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906580/ https://www.ncbi.nlm.nih.gov/pubmed/24523721 http://dx.doi.org/10.3389/fimmu.2014.00010 |
Ejemplares similares
-
ImmuneDB, a Novel Tool for the Analysis, Storage, and Dissemination of Immune Repertoire Sequencing Data
por: Rosenfeld, Aaron M., et al.
Publicado: (2018) -
Computational Evaluation of B-Cell Clone Sizes in Bulk Populations
por: Rosenfeld, Aaron M., et al.
Publicado: (2018) -
The analysis of clonal expansions in normal and autoimmune B cell repertoires
por: Hershberg, Uri, et al.
Publicado: (2015) -
ED SUMM: B cell VH region repertoire sequencing of 8 anatomical sites in 6 human donors reveals distinct networks of clone distribution: An atlas of B cell clonal distribution in the human body
por: Meng, Wenzhao, et al.
Publicado: (2017) -
Persistence and selection of an expanded B-cell clone in the setting of rituximab therapy for Sjögren’s syndrome
por: Hershberg, Uri, et al.
Publicado: (2014)