CNX-012-570, a direct AMPK activator provides strong glycemic and lipid control along with significant reduction in body weight; studies from both diet-induced obese mice and db/db mice models

OBJECTIVES: AMP activated protein kinase (AMPK) regulates the coordination of anabolic and catabolic processes and is an attractive therapeutic target for T2DM, obesity and metabolic syndrome. We report the anti-hyperglycemic and anti-hyperlipidemic effects of CNX-012-570 is an orally bioavailable s...

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Detalles Bibliográficos
Autores principales: Anil, Tharappel M, Harish, Chandrashekaran, Lakshmi, Mudigere N, Harsha, KrishnaReddy, Onkaramurthy, Mallappa, Sathish Kumar, Venkatesh, Shree, Nitya, Geetha, Venkatachalaiah, Balamurali, Gundalmandikal V, Gopala, Aralakuppe S, Madhusudhan Reddy, Bobbili, Govind, Madabosse K, Anup, Mammen O, Moolemath, Yoganand, Venkataranganna, Marikunte V, Jagannath, Madanahalli R, Somesh, Baggavalli P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Original Investigation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906767/
https://www.ncbi.nlm.nih.gov/pubmed/24460834
http://dx.doi.org/10.1186/1475-2840-13-27

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