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A new pharmacological role for donepezil: attenuation of morphine-induced tolerance and apoptosis in rat central nervous system
BACKGROUND: Tolerance to the analgesic effect of opioids is a pharmacological phenomenon that occurs after their prolonged administration. It has been shown that morphine-induced tolerance is associated with apoptosis in the central nervous system and neuroprotective agents which prevented apoptosis...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906771/ https://www.ncbi.nlm.nih.gov/pubmed/24455992 http://dx.doi.org/10.1186/1423-0127-21-6 |