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Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system
The influence of CD25(+)CD4(+) regulatory T cells (Treg) on acute and chronic viral infection of the central nervous system (CNS) was examined using a glial tropic murine coronavirus. Treg in the CNS were highest during initial T cell mediated virus control, decreased and then remained relatively st...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Authors. Published by Elsevier Inc.
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906923/ https://www.ncbi.nlm.nih.gov/pubmed/24210105 http://dx.doi.org/10.1016/j.virol.2013.08.030 |
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author | de Aquino, Maria Teresa P. Puntambekar, Shweta S. Savarin, Carine Bergmann, Cornelia C. Phares, Timothy W. Hinton, David R. Stohlman, Stephen A. |
author_facet | de Aquino, Maria Teresa P. Puntambekar, Shweta S. Savarin, Carine Bergmann, Cornelia C. Phares, Timothy W. Hinton, David R. Stohlman, Stephen A. |
author_sort | de Aquino, Maria Teresa P. |
collection | PubMed |
description | The influence of CD25(+)CD4(+) regulatory T cells (Treg) on acute and chronic viral infection of the central nervous system (CNS) was examined using a glial tropic murine coronavirus. Treg in the CNS were highest during initial T cell mediated virus control, decreased and then remained relatively stable during persistence. Anti-CD25 treatment did not affect CNS recruitment of inflammatory cells. Viral control was initially delayed; however, neither the kinetics of viral control nor viral persistence were affected. By contrast, the absence of Treg during the acute phase resulted in increased demyelination during viral persistence. These data suggest that CNS inflammation, progression of viral control and viral persistence are relatively independent of CD25(+)CD4(+) Treg. However, their absence during acute infection alters the ability of the host to limit tissue damage. |
format | Online Article Text |
id | pubmed-3906923 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | The Authors. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-39069232014-01-30 Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system de Aquino, Maria Teresa P. Puntambekar, Shweta S. Savarin, Carine Bergmann, Cornelia C. Phares, Timothy W. Hinton, David R. Stohlman, Stephen A. Virology Article The influence of CD25(+)CD4(+) regulatory T cells (Treg) on acute and chronic viral infection of the central nervous system (CNS) was examined using a glial tropic murine coronavirus. Treg in the CNS were highest during initial T cell mediated virus control, decreased and then remained relatively stable during persistence. Anti-CD25 treatment did not affect CNS recruitment of inflammatory cells. Viral control was initially delayed; however, neither the kinetics of viral control nor viral persistence were affected. By contrast, the absence of Treg during the acute phase resulted in increased demyelination during viral persistence. These data suggest that CNS inflammation, progression of viral control and viral persistence are relatively independent of CD25(+)CD4(+) Treg. However, their absence during acute infection alters the ability of the host to limit tissue damage. The Authors. Published by Elsevier Inc. 2013-12 2013-09-24 /pmc/articles/PMC3906923/ /pubmed/24210105 http://dx.doi.org/10.1016/j.virol.2013.08.030 Text en © 2013 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article de Aquino, Maria Teresa P. Puntambekar, Shweta S. Savarin, Carine Bergmann, Cornelia C. Phares, Timothy W. Hinton, David R. Stohlman, Stephen A. Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system |
title | Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system |
title_full | Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system |
title_fullStr | Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system |
title_full_unstemmed | Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system |
title_short | Role of CD25(+) CD4(+) T cells in acute and persistent coronavirus infection of the central nervous system |
title_sort | role of cd25(+) cd4(+) t cells in acute and persistent coronavirus infection of the central nervous system |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906923/ https://www.ncbi.nlm.nih.gov/pubmed/24210105 http://dx.doi.org/10.1016/j.virol.2013.08.030 |
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