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IL-27 inhibits epithelial-mesenchymal transition and angiogenic factor production in a STAT1-dominant pathway in human non-small cell lung cancer

BACKGROUND: Interleukin-27 signaling is mediated by the JAK-STAT pathway via activation of STAT1 and STAT3, which have tumor suppressive and oncogenic activities, respectively. Epithelial–mesenchymal transition (EMT) and angiogenesis are key processes in carcinogenesis. Although IL-27 has been shown...

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Detalles Bibliográficos
Autores principales:	Kachroo, Puja, Lee, Mi-Heon, Zhang, Ling, Baratelli, Felicita, Lee, Gina, Srivastava, Minu K, Wang, Gerald, Walser, Tonya C, Krysan, Kostyantyn, Sharma, Sherven, Dubinett, Steven M, Lee, Jay M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2013
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906956/ https://www.ncbi.nlm.nih.gov/pubmed/24274066 http://dx.doi.org/10.1186/1756-9966-32-97

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