Novel Germline Mutation in the Transmembrane Domain of HER2 in Familial Lung Adenocarcinomas

We encountered a family of Japanese descent in which multiple members developed lung cancer. Using whole-exome sequencing, we identified a novel germline mutation in the transmembrane domain of the human epidermal growth factor receptor 2 (HER2) gene (G660D). A novel somatic mutation (V659E) was als...

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Detalles Bibliográficos
Autores principales: Yamamoto, Hiromasa, Higasa, Koichiro, Sakaguchi, Masakiyo, Shien, Kazuhiko, Soh, Junichi, Ichimura, Koichi, Furukawa, Masashi, Hashida, Shinsuke, Tsukuda, Kazunori, Takigawa, Nagio, Matsuo, Keitaro, Kiura, Katsuyuki, Miyoshi, Shinichiro, Matsuda, Fumihiko, Toyooka, Shinichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2013
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3906987/
https://www.ncbi.nlm.nih.gov/pubmed/24317180
http://dx.doi.org/10.1093/jnci/djt338

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