ADP-Ribosylation: Activation, Recognition, and Removal

ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work...

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Detalles Bibliográficos
Autores principales: Li, Nan, Chen, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korea Society for Molecular and Cellular Biology 2014
Materias:
Minireview
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907000/
https://www.ncbi.nlm.nih.gov/pubmed/24552704
http://dx.doi.org/10.14348/molcells.2014.2245
Descripción
Sumario:ADP-ribosylation is a type of posttranslational modification catalyzed by members of the poly(ADP-ribose) (PAR) polymerase superfamily. ADP-ribosylation is initiated by PARPs, recognized by PAR binding proteins, and removed by PARG and other ADP-ribose hydrolases. These three groups of proteins work together to regulate the cellular and molecular response of PAR signaling, which is critical for a wide range of cellular and physiological functions.

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