Cargando…

Parasite-Antigen Driven Expansion of IL-5(−) and IL-5(+) Th2 Human Subpopulations in Lymphatic Filariasis and Their Differential Dependence on IL-10 and TGFβ

BACKGROUND: Two different Th2 subsets have been defined recently on the basis of IL-5 expression – an IL-5(+)Th2 subset and an IL-5(−)Th2 subset in the setting of allergy. However, the role of these newly described CD4(+) T cells subpopulations has not been explored in other contexts. METHODS: To st...

Descripción completa

Detalles Bibliográficos
Autores principales:	Anuradha, Rajamanickam, George, Parakkal Jovvian, Hanna, Luke E., Chandrasekaran, Vedachalam, Kumaran, P. Paul, Nutman, Thomas B., Babu, Subash
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907332/ https://www.ncbi.nlm.nih.gov/pubmed/24498448 http://dx.doi.org/10.1371/journal.pntd.0002658

Ejemplares similares

Expansion of Parasite-Specific CD4(+) and CD8(+) T Cells Expressing IL-10 Superfamily Cytokine Members and Their Regulation in Human Lymphatic Filariasis
por: Anuradha, Rajamanickam, et al.
Publicado: (2014)

Helminth Infections Coincident with Active Pulmonary Tuberculosis Inhibit Mono- and Multifunctional CD4(+) and CD8(+) T Cell Responses in a Process Dependent on IL-10
por: George, Parakkal Jovvian, et al.
Publicado: (2014)

IL-10- and TGFβ-mediated Th9 Responses in a Human Helminth Infection
por: Anuradha, Rajamanickam, et al.
Publicado: (2016)

Altered Circulating Levels of Matrix Metalloproteinases and Inhibitors Associated with Elevated Type 2 Cytokines in Lymphatic Filarial Disease
por: Anuradha, Rajamanickam, et al.
Publicado: (2012)

IL-27 and TGFβ mediated expansion of Th1 and adaptive regulatory T cells expressing IL-10 correlates with bacterial burden and disease severity in pulmonary tuberculosis
por: Kumar, Nathella P, et al.
Publicado: (2015)

Evidence of Microbial Translocation Associated with Perturbations in T Cell and Antigen-Presenting Cell Homeostasis in Hookworm Infections
por: George, Palakkal Jovvian, et al.
Publicado: (2012)

Circulating Microbial Products and Acute Phase Proteins as Markers of Pathogenesis in Lymphatic Filarial Disease
por: Anuradha, R., et al.
Publicado: (2012)

Modulation of Mycobacterium tuberculosis-specific humoral immune responses is associated with Strongyloides stercoralis co-infection
por: Anuradha, Rajamanickam, et al.
Publicado: (2017)

HepG2 hepatocytes express IFN-γ, TNF-α, TGF-β, M-CSF, oncostatin-M, ICAM-1, IL-4, IL-5, IL-7, IL-10, IL-11, IL-12 and IL-6 receptor genes in vitro
por: Russwurm, S, et al.
Publicado: (1998)

Combining Biologics Targeting Eosinophils (IL-5/IL-5R), IgE, and IL-4/IL-13 in Allergic and Inflammatory Diseases
por: Pitlick, Mitchell M., et al.
Publicado: (2022)

IL-33 Enhanced the Proliferation and Constitutive Production of IL-13 and IL-5 by Fibrocytes
por: Hayashi, Hisako, et al.
Publicado: (2014)

Allergic Rhinitis and Its Relationship with IL-10, IL-17, TGF-β, IFN-γ, IL 22, and IL-35
por: Bayrak Degirmenci, P., et al.
Publicado: (2018)

Review of Dancing Parasites in Lymphatic Filariasis
por: Dietrich, Christoph F., et al.
Publicado: (2019)

Elevated Systemic and Parasite—Antigen Stimulated Levels of Type III IFNs in a Chronic Helminth Infection and Reversal Following Anthelmintic Treatment
por: Rajamanickam, Anuradha, et al.
Publicado: (2018)

Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β
por: Bonne-Année, Sandra, et al.
Publicado: (2019)

Expression analysis of cytokines IL-5, IL-6, IL-8, IL-17 and VEGF in breast cancer patients
por: Liu, Gang, et al.
Publicado: (2022)

Decreased Prevalence of Lymphatic Filariasis among Diabetic Subjects Associated with a Diminished Pro-Inflammatory Cytokine Response (CURES 83)
por: Aravindhan, Vivekanandhan, et al.
Publicado: (2010)

Coincident Helminth Infection Modulates Systemic Inflammation and Immune Activation in Active Pulmonary Tuberculosis
por: George, Parakkal Jovvian, et al.
Publicado: (2014)

Serum and local IL-4, IL-5, IL-13 and immunoglobulin E in allergic rhinitis
por: Vlaykov, Atanas Nachev, et al.
Publicado: (2020)

Mobilization permits reliable ELISPOT detection of long-term memory T cells secreting IFN-γ, IL-4, IL-5, and IL-17 without in vitro expansion
por: Ghosh, Jaya, et al.
Publicado: (2013)

Susceptibility to L. sigmodontis infection is highest in animals lacking IL-4R/IL-5 compared to single knockouts of IL-4R, IL-5 or eosinophils
por: Frohberger, Stefan J., et al.
Publicado: (2019)

IL-5, IL-8 and tgf-beta expressions in chronic rhinosinusitis patients with nasal polyps and their correlation to tissue's cellularity and disease relapsing
por: Anselmo-Lima, Wilma T, et al.
Publicado: (2013)

Regulatory effects of C5a on IL-17A, IL-17F, and IL-23
por: Grailer, Jamison J., et al.
Publicado: (2013)

Identification of an interleukin (IL)-25–dependent cell population that provides IL-4, IL-5, and IL-13 at the onset of helminth expulsion
por: Fallon, Padraic G., et al.
Publicado: (2006)

Targeting IL-5 in COPD
por: Narendra, Dharani K, et al.
Publicado: (2019)

Eosinophils, beyond IL-5
por: Esnault, Stephane, et al.
Publicado: (2021)

The expression analysis of IL-6, IL-18, IL-21, IL-23, and TGF-β mRNA in the nasal mucosa of patients with Allergic rhinitis
por: Mirzaei, Yousef, et al.
Publicado: (2022)

Effects of overexpression of IL-10, IL-12, TGF-β and IL-4 on allergen induced change in bronchial responsiveness
por: Fu, Chi-Ling, et al.
Publicado: (2006)

Tumor promoting roles of IL-10, TGF-β, IL-4, and IL-35: Its implications in cancer immunotherapy
por: Mirlekar, Bhalchandra
Publicado: (2022)

Age does not affect the efficacy of anti-IL-5/IL-5R in severe asthmatics
por: Principe, Stefania, et al.
Publicado: (2019)

IL-10 Indirectly Downregulates IL-4–Induced IgE Production by Human B Cells
por: Lin, Adora A., et al.
Publicado: (2018)

MDA—Lymphatic Filariasis
por: Ichimori, Kazuyo
Publicado: (2014)

Urban lymphatic filariasis
por: Simonsen, Paul E., et al.
Publicado: (2012)

Comparison of IL-33 and IL-5 family mediated activation of human eosinophils
por: Angulo, Evelyn L., et al.
Publicado: (2019)

Decreased Frequencies of Circulating CD4(+) T Follicular Helper Cells Associated with Diminished Plasma IL-21 in Active Pulmonary Tuberculosis
por: Kumar, Nathella Pavan, et al.
Publicado: (2014)

Switch from IL-5 to IL-5-Receptor α Antibody Treatment in Severe Eosinophilic Asthma
por: Drick, Nora, et al.
Publicado: (2020)

Treatment with IL5-/IL-5 receptor antagonists in drug reaction with eosinophilia and systemic symptoms (DRESS)
por: Gschwend, Anna, et al.
Publicado: (2022)

Treatment with interleukin (IL)-5/IL-5 receptor antibodies in patients with severe eosinophilic asthma and COPD
por: Drick, Nora, et al.
Publicado: (2022)

Does Toxoplasma gondii Infection Affect the Levels of IgE and Cytokines (IL-5, IL-6, IL-10, IL-12, and TNF-alpha)?
por: Matowicka-Karna, Joanna, et al.
Publicado: (2009)

Increased serum IL-2, IL-4, IL-5 and IL-12p70 levels in AChR subtype generalized myasthenia gravis
por: Huan, Xiao, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_jf6ihfuodglvfonus302vhl3ik