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A Chaperone-Assisted Degradation Pathway Targets Kinetochore Proteins to Ensure Genome Stability

Cells are regularly exposed to stress conditions that may lead to protein misfolding. To cope with this challenge, molecular chaperones selectively target structurally perturbed proteins for degradation via the ubiquitin-proteasome pathway. In mammals the co-chaperone BAG-1 plays an important role i...

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Detalles Bibliográficos
Autores principales:	Kriegenburg, Franziska, Jakopec, Visnja, Poulsen, Esben G., Nielsen, Sofie Vincents, Roguev, Assen, Krogan, Nevan, Gordon, Colin, Fleig, Ursula, Hartmann-Petersen, Rasmus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907333/ https://www.ncbi.nlm.nih.gov/pubmed/24497846 http://dx.doi.org/10.1371/journal.pgen.1004140

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