Re-sequencing Expands Our Understanding of the Phenotypic Impact of Variants at GWAS Loci

Genome-wide association studies (GWAS) have identified >500 common variants associated with quantitative metabolic traits, but in aggregate such variants explain at most 20–30% of the heritable component of population variation in these traits. To further investigate the impact of genotypic varia...

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Detalles Bibliográficos
Autores principales: Service, Susan K., Teslovich, Tanya M., Fuchsberger, Christian, Ramensky, Vasily, Yajnik, Pranav, Koboldt, Daniel C., Larson, David E., Zhang, Qunyuan, Lin, Ling, Welch, Ryan, Ding, Li, McLellan, Michael D., O'Laughlin, Michele, Fronick, Catrina, Fulton, Lucinda L., Magrini, Vincent, Swift, Amy, Elliott, Paul, Jarvelin, Marjo-Riitta, Kaakinen, Marika, McCarthy, Mark I., Peltonen, Leena, Pouta, Anneli, Bonnycastle, Lori L., Collins, Francis S., Narisu, Narisu, Stringham, Heather M., Tuomilehto, Jaakko, Ripatti, Samuli, Fulton, Robert S., Sabatti, Chiara, Wilson, Richard K., Boehnke, Michael, Freimer, Nelson B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907339/
https://www.ncbi.nlm.nih.gov/pubmed/24497850
http://dx.doi.org/10.1371/journal.pgen.1004147

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