High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms

3% of the population develops saccular intracranial aneurysms (sIAs), a complex trait, with a sporadic and a familial form. Subarachnoid hemorrhage from sIA (sIA-SAH) is a devastating form of stroke. Certain rare genetic variants are enriched in the Finns, a population isolate with a small founder p...

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Detalles Bibliográficos
Autores principales: Kurki, Mitja I., Gaál, Emília Ilona, Kettunen, Johannes, Lappalainen, Tuuli, Menelaou, Androniki, Anttila, Verneri, van 't Hof, Femke N. G., von und zu Fraunberg, Mikael, Helisalmi, Seppo, Hiltunen, Mikko, Lehto, Hanna, Laakso, Aki, Kivisaari, Riku, Koivisto, Timo, Ronkainen, Antti, Rinne, Jaakko, Kiemeney, Lambertus A. L., Vermeulen, Sita H., Kaunisto, Mari A., Eriksson, Johan G., Aromaa, Arpo, Perola, Markus, Lehtimäki, Terho, Raitakari, Olli T., Salomaa, Veikko, Gunel, Murat, Dermitzakis, Emmanouil T., Ruigrok, Ynte M., Rinkel, Gabriel J. E., Niemelä, Mika, Hernesniemi, Juha, Ripatti, Samuli, de Bakker, Paul I. W., Palotie, Aarno, Jääskeläinen, Juha E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907358/
https://www.ncbi.nlm.nih.gov/pubmed/24497844
http://dx.doi.org/10.1371/journal.pgen.1004134

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