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Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice

BACKGROUND: Alzheimer’s disease (AD) is a severe neurodegenerative disease for which there is currently no effective treatment. The purpose of this study was to investigate whether repeated electroacupuncture (EA) stimulation would improve cognitive function and the pathological features of AD in am...

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Autores principales: Li, Xuying, Guo, Fan, Zhang, Qiaomei, Huo, Tingting, Liu, Lixin, Wei, Haidong, Xiong, Lize, Wang, Qiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907495/
https://www.ncbi.nlm.nih.gov/pubmed/24447795
http://dx.doi.org/10.1186/1472-6882-14-37
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author Li, Xuying
Guo, Fan
Zhang, Qiaomei
Huo, Tingting
Liu, Lixin
Wei, Haidong
Xiong, Lize
Wang, Qiang
author_facet Li, Xuying
Guo, Fan
Zhang, Qiaomei
Huo, Tingting
Liu, Lixin
Wei, Haidong
Xiong, Lize
Wang, Qiang
author_sort Li, Xuying
collection PubMed
description BACKGROUND: Alzheimer’s disease (AD) is a severe neurodegenerative disease for which there is currently no effective treatment. The purpose of this study was to investigate whether repeated electroacupuncture (EA) stimulation would improve cognitive function and the pathological features of AD in amyloid precursor protein (APP)/presenilin 1 (PS1) double transgenic mice. METHODS: Cognitive function of APP/PS1 double transgenic mice was assessed using the Morris water maze test before and after EA treatment. Levels of amyloid β-peptide (Aβ) deposits in the hippocampus and cortex were evaluated by immunofluorescence, western blot and enzyme-linked immunosorbent assay. Expression of brain-derived neurotrophic factor (BDNF) was also examined by immunofluorescence and western blot. The neurogenesis was labeled by the DNA marker bromodeoxyuridine. RESULTS: EA stimulation significantly ameliorated the learning and memory deficits of AD mice by shortening escape latency and increasing the time spent in the target zone during the probe test. Additionally, decreased Aβ deposits and increased BDNF expression and neurogenesis in the hippocampus and cortex of EA-treated AD mice were detected. The same change was detected in wild-type mice after EA treatment compared with wild-type mice without EA treatment. CONCLUSIONS: Repeated EA stimulation may improve cognitive function, attenuate Aβ deposits, up-regulate the expression of BDNF and promote neurogenesis in the APP/PS1 double transgenic mice. This suggests that EA may be a promising treatment for AD.
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spelling pubmed-39074952014-01-31 Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice Li, Xuying Guo, Fan Zhang, Qiaomei Huo, Tingting Liu, Lixin Wei, Haidong Xiong, Lize Wang, Qiang BMC Complement Altern Med Research Article BACKGROUND: Alzheimer’s disease (AD) is a severe neurodegenerative disease for which there is currently no effective treatment. The purpose of this study was to investigate whether repeated electroacupuncture (EA) stimulation would improve cognitive function and the pathological features of AD in amyloid precursor protein (APP)/presenilin 1 (PS1) double transgenic mice. METHODS: Cognitive function of APP/PS1 double transgenic mice was assessed using the Morris water maze test before and after EA treatment. Levels of amyloid β-peptide (Aβ) deposits in the hippocampus and cortex were evaluated by immunofluorescence, western blot and enzyme-linked immunosorbent assay. Expression of brain-derived neurotrophic factor (BDNF) was also examined by immunofluorescence and western blot. The neurogenesis was labeled by the DNA marker bromodeoxyuridine. RESULTS: EA stimulation significantly ameliorated the learning and memory deficits of AD mice by shortening escape latency and increasing the time spent in the target zone during the probe test. Additionally, decreased Aβ deposits and increased BDNF expression and neurogenesis in the hippocampus and cortex of EA-treated AD mice were detected. The same change was detected in wild-type mice after EA treatment compared with wild-type mice without EA treatment. CONCLUSIONS: Repeated EA stimulation may improve cognitive function, attenuate Aβ deposits, up-regulate the expression of BDNF and promote neurogenesis in the APP/PS1 double transgenic mice. This suggests that EA may be a promising treatment for AD. BioMed Central 2014-01-22 /pmc/articles/PMC3907495/ /pubmed/24447795 http://dx.doi.org/10.1186/1472-6882-14-37 Text en Copyright © 2014 Li et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Li, Xuying
Guo, Fan
Zhang, Qiaomei
Huo, Tingting
Liu, Lixin
Wei, Haidong
Xiong, Lize
Wang, Qiang
Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
title Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
title_full Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
title_fullStr Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
title_full_unstemmed Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
title_short Electroacupuncture decreases cognitive impairment and promotes neurogenesis in the APP/PS1 transgenic mice
title_sort electroacupuncture decreases cognitive impairment and promotes neurogenesis in the app/ps1 transgenic mice
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907495/
https://www.ncbi.nlm.nih.gov/pubmed/24447795
http://dx.doi.org/10.1186/1472-6882-14-37
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