The Mechanism of Intralipid®-Mediated Cardioprotection Complex IV Inhibition by the Active Metabolite, Palmitoylcarnitine, Generates Reactive Oxygen Species and Activates Reperfusion Injury Salvage Kinases

BACKGROUND: Intralipid® administration at reperfusion elicits protection against myocardial ischemia-reperfusion injury. However, the underlying mechanisms are not fully understood. METHODS: Sprague-Dawley rat hearts were exposed to 15 min of ischemia and 30 min of reperfusion in the absence or pres...

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Detalles Bibliográficos
Autores principales: Lou, Phing-How, Lucchinetti, Eliana, Zhang, Liyan, Affolter, Andreas, Schaub, Marcus C., Gandhi, Manoj, Hersberger, Martin, Warren, Blair E., Lemieux, Hélène, Sobhi, Hany F., Clanachan, Alexander S., Zaugg, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907505/
https://www.ncbi.nlm.nih.gov/pubmed/24498043
http://dx.doi.org/10.1371/journal.pone.0087205

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