Variant B Cell Receptor Isotype Functions Differ in Hairy Cell Leukemia with Mutated BRAF and IGHV Genes

A functional B-cell receptor (BCR) is critical for survival of normal B-cells, but whether it plays a comparable role in B-cell malignancy is as yet not fully delineated. Typical Hairy Cell Leukemia (HCL) is a rare B-cell tumor, and unique in expressing multiple surface immunoglobulin (sIg) isotypes...

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Detalles Bibliográficos
Autores principales: Weston-Bell, Nicola J., Forconi, Francesco, Kluin-Nelemans, Hanneke C., Sahota, Surinder S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3907534/
https://www.ncbi.nlm.nih.gov/pubmed/24497953
http://dx.doi.org/10.1371/journal.pone.0086556

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